D-GET: Group-Enhanced Transformer for Diabetic Retinopathy Severity Classification in Fundus Fluorescein Angiography.

Early detection of Diabetic Retinopathy (DR) is vital for preserving vision and preventing deterioration of eyesight. Fundus Fluorescein Angiography (FFA), recognized as the gold standard for diagnosing DR, effectively reveals abnormalities in retinal vasculature. Given the labor-intensive and costl...

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Publicado en:Journal of Medical Systems Vol. 49; no. 1; pp. 1 - 16
Autores principales: Liu, Xina, Xie, Jun, Hou, Junjun, Xu, Xinying, Guo, Yan
Formato: diagnostic images equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature 3/6/2025
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10916-025-02165-4
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        atl: D-GET: Group-Enhanced Transformer for Diabetic Retinopathy Severity Classification in Fundus Fluorescein Angiography.
      aug:
        au:
          Liu, Xina
          Xie, Jun
          Hou, Junjun
          Xu, Xinying
          Guo, Yan
        affil: https://ror.org/03kv08d37 College of Electrical and Power Engineering, Taiyuan University of Technology, 030002, Taiyuan, Shanxi, China
      sug:
        subj:
          Algorithms Utilization
          Deep Learning
          Diabetic Retinopathy Classification
          Diabetic Retinopathy Radiography
          Angiography Methods
          Fluorescent Dyes
          Severity of Illness Evaluation
          Diabetic Retinopathy Diagnosis
          Human
          Funding Source
          Early Diagnosis
          Retinal Diseases Prevention and Control
          Diagnostic Imaging Economics
          Convolutional Neural Networks
          Image Processing, Computer Assisted
          Machine Learning
          Factor Analysis
          Proxy
          Descriptive Statistics
          Data Analysis Software
          Data Curation
          Precision
          Sensitivity and Specificity
          Validity
          Radiographic Image Enhancement
          T-Tests
          Wilcoxon Signed Rank Test
      ab: Early detection of Diabetic Retinopathy (DR) is vital for preserving vision and preventing deterioration of eyesight. Fundus Fluorescein Angiography (FFA), recognized as the gold standard for diagnosing DR, effectively reveals abnormalities in retinal vasculature. Given the labor-intensive and costly nature of manual DR diagnosis, along with its low accuracy, developing a DR classification model based on FFA using deep learning techniques is crucial. Furthermore, DR classification faces challenges such as minimal lesion variance between different disease stages and significant size variations of lesions within the same stage, with small lesions often overlooked by existing models. We propose a deep learning model, D-GET, utilizing a Group-Enhanced Transformer for classifying DR lesion severity in FFA images. The D-GET model incorporates a Full-Scale Transformer Block, where the Group-Focal module captures feature information at multiple scales, from fine details to broader patterns, and adaptively integrates contextual information, enhancing the model's ability to detect small-scale lesions. The model also includes a Channel Adaptive Attention Module (CAAM) that synthesizes channel and spatial information to improve feature detection and localization. Experimental findings indicate that the D-GET method we developed surpasses existing methods on a custom dataset. The D-GET model, developed for DR classification using FFA images, significantly improves the detection of small-scale lesions. This advancement enhances the diagnosis and treatment of DR, establishing a solid foundation for its broader application across various domains of ophthalmic and general medical imaging.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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