Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe.
Background: Studying the mechanisms Involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associate...
| Publicado en: | Nefrología Vol. 45; no. 3; pp. 238 - 249 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artículo |
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Revista Nefrologia
Mar2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=183502712&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 183502712 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 02116995 50C3 jtl: Nefrología issn: 02116995 maglogo: N pubinfo: dt: Mar2025 vid: 45 iid: 3 pid: 39358 pub: Revista Nefrologia artinfo: ui: 183502712 10.1016/j.nefro.2024.10.003 ppf: 238 ppct: 11 formats: fmt: @attributes: type: P size: 1.1MB tig: atl: Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe. aug: au: Mas-Fontao, Sebastián Civantos, Esther Boukichou-Abdelkader, Nisa Soto-Catalan, Manuel Romeo-Colas, Marta Marco, Arantxa Gomez-Guerrero, Carmen Moreno, Juan Antonio Tuomilehto, Jaakko Gabriel, Rafael Egido, Jesús affil: Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain Faculty of Medicine and Biomedicine, Universidad Alfonso X el Sabio (UAX), Madrid, Spain EVIDEM CONSULTORES, Madrid, Spain Asociación para la Investigación y Prevención de la Diabetes y Enfermedades Cardiovasculares (PREDICOR), Madrid, Spain Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Hospital Universitario Reina Sofía, Cordoba, Spain World Community for Prevention of Diabetes Foundation (WCPD), Madrid, Spain Finnish Institute for Health and Welfare, Helsinki, Finland Department of Public Health, University of Helsinki, Helsinki, Finland Departamento de Salud Internacional, Escuela Nacional de Sanidad, Instituto de Salud Carlos III, Madrid, Spain su: Prediabetic state Type 2 diabetes Oxidative stress Chronic kidney failure Fatty liver sug: subj: Prediabetic state Type 2 diabetes Oxidative stress Chronic kidney failure Fatty liver keyword: Biomarkers Chronic kidney disease Prediabetes Biomarcadores Diabetes tipo 2 Enfermedad renal crónica Estrés oxidativo ab: Background: Studying the mechanisms Involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe. Methods:In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein - CRP; Interleukin 6 - IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement. Results:Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid profile, and fatty liver index. In particular, both types of biomarkers were associated with components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied. Conclusion:These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggests that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes. Antecedentes: El estudio de los mecanismos implicados en la transición de la prediabetes a la diabetes y sus complicaciones asociadas, como la enfermedad renal, es un tema de gran interés. Este estudio se centra en la identificación de biomarcadores eficaces para la detección precoz de la afectación renal, evaluando moléculas asociadas al estrés oxidativo e inflamación en individuos prediabéticos de varios países europeos. Métodos:En muestras de plasma de individuos prediabéticos, incluidos en el estudio ePREDICE, se determinaron biomarcadores de estrés oxidativo (AOPP) e inflamación (proteína C reactiva, IL-6) y se correlacionaron con datos antropométricos y bioquímicos, evaluando su potencial en el diagnóstico precoz de la disfunción renal. Resultados:Entre los 967 sujetos con prediabetes, 94 presentaban algún signo de afectación renal, como albuminuria, hiperfiltración o hipofiltración. Se identificaron variaciones significativas entre los biomarcadores de estrés oxidativo e inflamatorios (cuartiles superiores e inferior del AOPP, PCR e IL-6) y parámetros relacionados como la presión arterial, el metabolismo glucémico, el perfil lipídico y el índice de hígado graso. En particular, ambos biomarcadores estaban bien relacionados con los componentes del síndrome metabólico. Existieron asociaciones significativas entre la AOPP y la PCR, y la presencia de albuminuria, pero no con la función renal. En general, la PCR fue mejor biomarcador que la IL-6 para la mayoría de los parámetros estudiados. Conclusiones:Estos resultados subrayan las importantes conexiones entre estrés oxidativo e inflamación con las anomalías metabólicas ligadas al estado prediabético y sus complicaciones como el hígado graso y la afectación renal. Aunque es necesario confirmar estos datos, nuestro estudio sugiere que los AOPP y la PCR podrían ser biomarcadores de interés en la predicción del riesgo de pérdida de la función renal en los sujetos con prediabetes. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Nefrología is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Nefrología holder: Revista Nefrologia dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
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