Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors.
Rationale: Alcohol is one of the most frequently used drugs of abuse and has a major impact on human health worldwide. People assigned female at birth and those with adverse childhood experiences are stress-vulnerable and more likely to report drinking as a means of "self-medication." Prior studies...
| Publicado en: | Psychopharmacology Vol. 242; no. 4; pp. 763 - 782 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183536981&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183536981 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Apr2025 vid: 242 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183536981 182769090 10.1007/s00213-025-06749-3 183536981 ppf: 763 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors. aug: au: McElroy, Bryan D. Li, Chen McCloskey, Nicholas S. Alberici, Amber R. Kirby, Lynn G. affil: https://ror.org/00kx1jb78 Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, 3500 N. Broad St, MERB Room 857, 19140, Philadelphia, PA, USA sug: ab: Rationale: Alcohol is one of the most frequently used drugs of abuse and has a major impact on human health worldwide. People assigned female at birth and those with adverse childhood experiences are stress-vulnerable and more likely to report drinking as a means of "self-medication." Prior studies in our laboratory showed that adolescent social isolation stress (SIS) increases vulnerability to ethanol (EtOH) intake and consumption despite negative consequences in female rats. Objectives: Here, we explored modulation of the dorsal raphe nucleus (DRN)-serotonin (5-HT) system, a sexually dimorphic neurotransmitter system involved in stress-reward interactions, to determine its contribution to EtOH-motivated behaviors in rats that have undergone SIS. Results: We employed electrophysiological and functional neuroanatomy strategies to show that both SIS and EtOH exposure induce persistent hypofunction of the DRN 5-HT system, particularly in females. Chemogenetic activation of DRN 5-HT neurons attenuated reward value for both EtOH and sucrose and elevated punished responding for EtOH in a stress-dependent manner. Conclusions: Our results highlight an inverse relationship between EtOH consumption and the 5-HT system, the sex- and stress-dependent nature of this relationship, and a connection between DRN 5-HT signaling and acute responding to rewards and punishment. These data support the DRN 5-HT system as a potential target to treat aberrant alcohol consumption and drinking despite negative consequences in stress-vulnerable populations. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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