Alteration of dynamical degree centrality in brain functional network and its association with metabolic disorder in minimal hepatic encephalopathy.
Purpose: To investigate dynamical degree centrality (dDC) alteration and its association with metabolic disturbance and cognitive impairment in minimal hepatic encephalopathy (MHE). Methods: Fifty-eight cirrhotic patients (22 with MHE, 36 without MHE [NHE]) and 25 healthy controls underwent resting-...
| Published in: | Neuroradiology Vol. 67; no. 2; pp. 371 - 382 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Feb2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183578032&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183578032 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Feb2025 vid: 67 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183578032 179993252 183578032 183578032 10.1007/s00234-024-03470-4 183578032 ppf: 371 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Alteration of dynamical degree centrality in brain functional network and its association with metabolic disorder in minimal hepatic encephalopathy. aug: au: Huang, Hui-Wei Liu, Rong-Hua Zeng, Jing-Yi Li, Dan Li, Jian-Qi Chen, Hua-Jun affil: https://ror.org/055gkcy74 Department of Radiology, Fujian Medical University Union Hospital, 350001, Fuzhou, China sug: subj: Brain Radiography Brain Physiology Hepatic Encephalopathy Metabolism Hepatic Encephalopathy Physiopathology Cognition Evaluation Human Male Female Middle Age Funding Source Case Control Studies Neuropsychological Tests Psychometrics Proton Magnetic Resonance Spectroscopy Methods Scales Cerebral Cortex Metabolism Parietal Lobe Metabolism Glutamic Acid Metabolism Glutamine Metabolism Creatinine Blood Inositol Blood Choline Blood T Lymphocytes Analysis Aspartic Acid Blood Frontal Lobe Metabolism Descriptive Statistics Data Analysis Software Magnetic Resonance Imaging Methods China Middle Aged: 45-64 years Male Female ab: Purpose: To investigate dynamical degree centrality (dDC) alteration and its association with metabolic disturbance and cognitive impairment in minimal hepatic encephalopathy (MHE). Methods: Fifty-eight cirrhotic patients (22 with MHE, 36 without MHE [NHE]) and 25 healthy controls underwent resting-state functional magnetic resonance imaging, 1H-magnetic resonance spectroscopy, and neurocognitive examination based on the Psychometric Hepatic Encephalopathy Score (PHES). We obtained metabolite ratios in the bilateral posterior cingulate cortex and precuneus, including glutamate and glutamine (Glx)/total creatine (tCr), myo-inositol (mI)/tCr, total choline/tCr, and N-acetyl aspartate/tCr. For each voxel, degree centrality was calculated as the sum of its functional connectivity with other voxels in the brain; and sliding-window correlation was used to calculate dDC per voxel. Results: We observed a stepwise increase in Glx/tCr and a decrease in mI/tCr from NHE to MHE. The intergroup dDC differences were observed in the bilateral posterior cingulate cortex and precuneus (region of interest [ROI1]), bilateral superior-medial frontal gyrus and anterior cingulate cortex (ROI2), and left caudate head. The dDC in ROI2 (r = 0.450, P < 0.001) and mI/tCr (r = 0.297, P = 0.024) was correlated with PHES. Significant correlations were found between dDC in ROI1 and Glx/tCr (r = − 0.413, P = 0.001) and mI/tCr (r = 0.554, P < 0.001). The dDC in ROI2, Glx/tCr, and mI/tCr showed potential for distinguishing NHE from MHE (areas under the curve = 0.859, 0.655, and 0.672, respectively). Conclusion: Our findings suggested dynamic brain network disorganization in MHE, which was associated with metabolic derangement and neurocognitive impairment. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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