Clinical evidence of sesame (Sesamum indicum L.) products and its bioactive compounds on anthropometric measures, blood pressure, glycemic control, inflammatory biomarkers, lipid profile, and oxidative stress parameters in humans: a GRADE-assessed systematic review and dose–response meta-analysis
This comprehensive systematic review and meta-analysis aimed to assess the impact of sesame (Sesamum indicum L.) supplementation on cardiovascular disease risk factors. Relevant research was discovered via PubMed, Scopus, Web of Science, CENTRAL, and EMBASE up to June 2024. The assessment of study q...
| Publicado en: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 23 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research systematic review tables/charts Journal Article |
| Publicado: |
BioMed Central
3/11/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183596162&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183596162 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 3/11/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 183596162 183596162 183596162 10.1186/s12986-025-00910-7 183596162 ppf: 1 ppct: 22 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Clinical evidence of sesame (Sesamum indicum L.) products and its bioactive compounds on anthropometric measures, blood pressure, glycemic control, inflammatory biomarkers, lipid profile, and oxidative stress parameters in humans: a GRADE-assessed systematic review and dose–response meta-analysis aug: au: Jafari, Ali Parsi Nezhad, Bahare Rasaei, Niloufar Aleebrahim-Dehkordi, Elahe Rajabi, Abdolhalim Alaghi, Alireza affil: https://ror.org/034m2b326 Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Plants, Medicinal Pharmacodynamics Organic Chemicals Pharmacodynamics Anthropometry Blood Pressure Drug Effects Glycemic Control Drug Effects Inflammation Biological Markers Drug Effects Lipids Drug Effects Oxidative Stress Drug Effects Cardiovascular Risk Factors Prevention and Control Dose-Response Relationship, Drug Dietary Supplementation Human Systematic Review Meta Analysis PubMed Embase Glycated Hemoglobin Drug Effects C-Reactive Protein Drug Effects Interleukins Drug Effects Malondialdehyde Drug Effects Chronic Disease Prevention and Control Male Female Sex Factors Age Factors Middle Age Aged Aged, 80 and Over Plants, Medicinal Administration and Dosage Lipoproteins, HDL Drug Effects Checklists Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: This comprehensive systematic review and meta-analysis aimed to assess the impact of sesame (Sesamum indicum L.) supplementation on cardiovascular disease risk factors. Relevant research was discovered via PubMed, Scopus, Web of Science, CENTRAL, and EMBASE up to June 2024. The assessment of study quality was conducted using the Cochrane risk-of-bias tool. Thirteen trials, with interventions ranging from 4 to 12 weeks and involving 521 participants, demonstrated significant reductions in glycated hemoglobin (HbA1c) (Standardized Mean Difference [SMD] = − 0.67; 95% Confidence Interval [CI] − 1.01, − 0.32; P < 0.001), C-reactive protein (CRP) (SMD = − 0.51; 95% CI − 0.96, − 0.05; P = 0.028), and interleukin-6 (IL-6) (SMD = − 0.74; 95% CI − 1.16, − 0.32; P < 0.001), and a marginally significant effect on fasting blood sugar (FBS) (SMD = − 0.57; 95% CI − 1.16, 0.02; P = 0.057). Subgroup analyses revealed that sesame supplementation significantly reduced CRP and malondialdehyde (MDA) in populations without chronic diseases, while total cholesterol (TC) and MDA were reduced in those with chronic diseases. MDA was significantly reduced in females, especially those aged 50 or older. At dosages of 10 g per day or less, CRP, high-density lipoprotein cholesterol (HDL), and TC showed significant improvements. Meta-regression highlighted a significant dose-dependent reduction in TC levels at 10 g/day, and a significant duration-dependent decrease in TG levels at 8 weeks of supplementation. Sesame supplementation demonstrates potential benefits in improving glycemic control, inflammatory markers, and lipid profiles, making it a promising adjunct therapy for reducing cardiovascular disease risk factors. pubtype: Academic Journal doctype: meta analysis pictorial research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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