Bioassay-guided isolation and characterisation of α-glucosidase inhibitors from Sanghuangporus baumii.
Bioassay-guided fractionation of the isopropanol extract of the medicinal mushroom Sanghuangporus baumii led to the isolation and characterisation of a new acorane-type sesquiterpenoid bauminene (1) and seven known compounds 2–8. The planar structure of 1 was elucidated on the basis of extensive spe...
| Publicado en: | Natural Product Research Vol. 39; no. 6; pp. 1452 - 1461 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183684350&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183684350 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Mar2025 vid: 39 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 183684350 174597302 10.1080/14786419.2023.2300397 183684350 ppf: 1452 ppct: 9 formats: tig: atl: Bioassay-guided isolation and characterisation of α-glucosidase inhibitors from Sanghuangporus baumii. aug: au: Hu, Xiaoyan Wang, Yanling Lin, Yuhao Yang, Nini Yao, Junyi Shan, Weiguang Rao, Guiwei Ying, Youmin affil: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China sug: ab: Bioassay-guided fractionation of the isopropanol extract of the medicinal mushroom Sanghuangporus baumii led to the isolation and characterisation of a new acorane-type sesquiterpenoid bauminene (1) and seven known compounds 2–8. The planar structure of 1 was elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR and HR-ESI-MS. The relative configuration of 1 was determined by a combination of ROESY experiment, density functional theory calculation of 13C NMR, and DP4+ probability analysis, while the absolute configuration of 1 was established by comparative electronic circular dichroism (ECD) spectra analysis. In the in vitro bioassay, compounds 1–8 exhibited potent to moderate α-glucosidase inhibitory activity with IC50 values ranging from 6.8 ± 0.68 to 221.4 ± 6.57 µM. The presences of these bioactive constituents in the sclerotia of S. baumii may be related to the use of the fungus as 'Sanghuang' for the adjuvant treatment of DM. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|