Population Pharmacokinetics and AUC‐Based Dose Optimization of Vancomycin in Chinese Neonates.
Objective: The primary objective of this study revolves around the development of a population pharmacokinetic (PPK) model for vancomycin in neonatal subjects, with the objective of providing a theoretical basis for judicious therapeutic interventions. Methods: In this study, a retrospective collect...
| Published in: | Journal of Clinical Pharmacy & Therapeutics Vol. 2025; no. 1; pp. 1 - 13 |
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| Main Authors: | , , , , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
3/12/2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183690904&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183690904 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: 3/12/2025 vid: 2025 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 183690904 183690904 183690904 10.1155/jcpt/6935260 183690904 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Population Pharmacokinetics and AUC‐Based Dose Optimization of Vancomycin in Chinese Neonates. aug: au: Yang, Caiyan Wei, Shifeng Wang, Bo Yang, Jiayu Zhao, Zhigang Xu, Daqing Mei, Shenghui Bondareva, Irina B. affil: Department of Pharmacy,, Yinchuan First People's Hospital,, 2 Liqun West Street Xingqing District, Yinchuan, 750001,, Ningxia, China sug: subj: Vancomycin Pharmacokinetics Vancomycin Blood Vancomycin Administration and Dosage Models, Statistical Administration, Intravenous Chinese Persons In Infancy and Childhood Human Retrospective Design Infant, Newborn China Male Female Dose-Response Relationship, Drug Intensive Care Units, Neonatal Descriptive Statistics Infant, Newborn: birth-1 month Male Female ab: Objective: The primary objective of this study revolves around the development of a population pharmacokinetic (PPK) model for vancomycin in neonatal subjects, with the objective of providing a theoretical basis for judicious therapeutic interventions. Methods: In this study, a retrospective collection encompassed 75 neonatal patients, contributing to a total of 89 vancomycin blood concentration monitoring datasets. The establishment of the PPK model is carried out utilizing the nonlinear mixed effects model methodology. The PPK model was constructed employing a one‐compartment model with proportional residual error, and the influence of covariates on pharmacokinetic parameters was systematically assessed through forward stepwise addition and backward elimination methods. The stability and predictive accuracy of the final model were assessed using goodness‐of‐fit plots, nonparametric bootstrap validation, visual predictive checks, and normalized prediction distribution errors. Furthermore, Monte Carlo simulations were employed to predict vancomycin concentrations in neonatal patients with typical characteristics. Results: The final PPK model yielded population‐typical values of 0.24 L/h for vancomycin clearance (CL). Noteworthy contributors to vancomycin CL were identified as body weight, gestational age, creatinine clearance rate (CLcr), and sex. Internal validation results of the model indicate that it possesses stability, efficacy, and demonstrates a favorable predictive capacity. Monte Carlo simulations indicate that for a male neonatal patient characterized by a gestational age of 37 weeks, a body weight of 2.5 kg, and a CLcr of 60 mL/min, the recommended dosing regimen is 25.5 to 41.5 mg every 8 h. Conclusion: This investigation has successfully formulated a PPK model for vancomycin in neonatal patients, offering the capacity to estimate individual CL. The dosing regimen for neonates should take into account factors such as body weight, gestational age, CLcr, and sex. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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