Identification of the Molecular Subtype and Prognostic Characteristics of Breast Cancer Based on Tumor‐Infiltrating Regulatory T Cells.
Background: T regulatory cells (Tregs) are essential for preserving immune tolerance. They are present in large numbers in many tumors, hindering potentially beneficial antitumor responses. However, their predictive significance for breast cancer (BC) remains ambiguous. This study aimed to explore g...
| Publicado en: | Breast Journal Vol. 2025; pp. 1 - 15 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
3/5/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183914231&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183914231 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: 3/5/2025 vid: 2025 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 183914231 183914231 183914231 10.1155/tbj/6913291 183914231 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Identification of the Molecular Subtype and Prognostic Characteristics of Breast Cancer Based on Tumor‐Infiltrating Regulatory T Cells. aug: au: Ma, Jianying Hu, Gang Kuang, Lianghong Zhu, Zhongzhong Wani, Imtiaz affil: Department of Breast Surgery,, Thyroid Surgery,, Huangshi Central Hospital,, Affiliated Hospital of Hubei Polytechnic University,, Huangshi, Hubei, China, hbpu.edu.cn sug: subj: Breast Neoplasms Prognosis T Lymphocytes Tumor Markers, Biological Human Gene Expression Profiling Algorithms Consensus Mutation Cluster Analysis Overall Survival Immune Checkpoint Inhibitors Immunotherapy Chemotherapy, Cancer Data Analysis Software Wilcoxon Rank Sum Test Pearson's Correlation Coefficient Kaplan-Meier Estimator Cox Proportional Hazards Model Funding Source ab: Background: T regulatory cells (Tregs) are essential for preserving immune tolerance. They are present in large numbers in many tumors, hindering potentially beneficial antitumor responses. However, their predictive significance for breast cancer (BC) remains ambiguous. This study aimed to explore genes associated with Tregs and develop a prognostic signature associated with Tregs. Methods: The gene expression and clinical data on BC were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The integration of CIBERSORT and weighted correlation network analysis (WGCNA) algorithms was utilized to identify modules associated with Tregs. The consensus cluster algorithm was utilized to create molecular subtypes determined by genes associated with Tregs. Then, a prognostic signature associated with Tregs was constructed and its relationship to tumor immunity and the prognosis was evaluated. Results: The blue module genes exhibited the most significant correlation with Tregs, and 1080 genes related to Tregs were acquired. A total of 93 genes from the TCGA dataset were found to have a significant impact on patient prognosis. Samples from BC were categorized into two clusters by consensus cluster analysis. The overall survival, immune checkpoint genes, molecular subtype, and biological behaviors varied significantly between these two subtypes. A 10‐gene signature developed from differentially expressed genes between two subtypes demonstrated consistent prognostic accuracy in both TCGA and GEO datasets. It functioned as a standalone prognostic marker for individuals with BC. In addition, patients with low risk are more inclined to exhibit increased immune cell infiltration, TME score, and tumor mutation burden (TMB). Meanwhile, Individuals classified within the low‐risk group showed better responses to immunotherapies compared to their counterparts in the high‐risk group. Conclusions: The prognostic model derived from Tregs‐related genes could aid in assessing the prognosis, guiding personalized treatment, and potentially enhancing the clinical outcomes for patients with BC. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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