Association Between Lipoprotein(a) and Dilatation of Different Aortic Segments in Hypertensive Patients.
Purpose: There are limited reports on the potential link between Lp(a) and ARDM. Thus, we examined the relationship between Lp(a) and ARDM among hypertensive patients. Methods: We used echocardiography to measure ARDM in 513 consecutively hospitalized patients. namely, the aortic valve annulus (Ava)...
| Publicado en: | Echocardiography Vol. 42; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183918208&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183918208 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Jan2025 vid: 42 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 183918208 183918208 183918208 10.1111/echo.70061 183918208 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Association Between Lipoprotein(a) and Dilatation of Different Aortic Segments in Hypertensive Patients. aug: au: Wang, Lin Ma, Chaoqun Liu, Xiaowei Han, Wei affil: Department of Cardiology, Zhejiang Hospital, Hangzhou Zhejiang,, China sug: subj: Lipoproteins Blood Vasodilation Aorta Pathology Hypertension Biological Markers China Funding Source Human Male Female Middle Age Aged Echocardiography Inpatients Aortic Valve Diseases Sinus of Valsalva Odds Ratio Confidence Intervals Age Factors Sex Factors T-Tests Mann-Whitney U Test Chi Square Test Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Multiple Logistic Regression Univariate Statistics Multivariate Statistics P-Value Data Analysis Software Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: There are limited reports on the potential link between Lp(a) and ARDM. Thus, we examined the relationship between Lp(a) and ARDM among hypertensive patients. Methods: We used echocardiography to measure ARDM in 513 consecutively hospitalized patients. namely, the aortic valve annulus (Ava), sinuses of Valsalva (SV), sinotubular junction (STJ), and ascending aorta (AA) in 513 consecutive inpatients. We also examined the Lp(a), and other laboratory profiles of all participants. Results: Lp(a) exhibited a positive and independent relationship with the SV diameter (coefficient [β] = 0.330, p = 0.002) and STJ (coefficient [β] = 0.253, p = 0.023), regardless of age, sex, height, or other clinical factors among hypertensive, but not nonhypertensive patients. We also demonstrated that a marked rise in Lp(a) levels was independently associated with SV dilatation (SVD) (OR: 1.006, 95% CI: 1.002–1.009, p = 0.002) and AA dilatation (AAD) (OR: 1.006, 95% CI: 1.000–1.011, p = 0.035) in patients with hypertension. In the subgroup analysis, elevated Lp(a) levels were significantly associated with SV dilatation in all subgroups, and with AAD in males and patients aged 65 years or younger (p < 0.05). The restricted cubic spline analysis indicated a linear association between Lp(a) levels and the risk of both SV and AAD (p < 0.05). Conclusions: Herein, we were the first to report that among hypertensive patients, elevated Lp(a) concentrations were intricately linked to the ARDMs at SV and STJ. Moreover, we revealed that the Lp(a) level was a stand‐alone indicator of SVD and AAD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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