Reference Ranges of Left Ventricular Global Longitudinal Strain by Contemporary Vendor‐Neutral Echocardiography Software in Healthy Subjects.

Background: Left ventricular global longitudinal strain (LVGLS) by speckle‐tracking transthoracic echocardiography (TTE) is an established measure of left ventricular systolic function with many clinical applications. Strain software has evolved to achieve vendor‐neutrality in recent developments, a...

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Publicado en:Echocardiography Vol. 42; no. 2; pp. 1 - 8
Autores principales: Arockiam, Aro Daniela, Dong, Tiffany, Agrawal, Ankit, Dahdah, Joseph El, Haroun, Elio, Majid, Muhammad, Sorathia, Sharmeen, Grimm, Richard A., Collier, Patrick, Rodriguez, Leonardo, Popovic, Zoran B., Griffin, Brian P., Wang, Tom Kai Ming
Formato: research tables/charts Journal Article
Publicado: Wiley-Blackwell Feb2025
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Wiley-Blackwell
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        10.1111/echo.70102
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        atl: Reference Ranges of Left Ventricular Global Longitudinal Strain by Contemporary Vendor‐Neutral Echocardiography Software in Healthy Subjects.
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          Arockiam, Aro Daniela
          Dong, Tiffany
          Agrawal, Ankit
          Dahdah, Joseph El
          Haroun, Elio
          Majid, Muhammad
          Sorathia, Sharmeen
          Grimm, Richard A.
          Collier, Patrick
          Rodriguez, Leonardo
          Popovic, Zoran B.
          Griffin, Brian P.
          Wang, Tom Kai Ming
        affil: Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, Sydell and Arnold Miller Heart, Vascular, and Thoracic Institute, Cleveland Ohio, , USA
      sug:
        subj:
          Heart Ventricle, Left
          Global Longitudinal Strain
          Reference Values
          Echocardiography Methods
          Software
          Human
          Cross Sectional Studies
          Prospective Studies
          Descriptive Statistics
          Data Analysis Software
          Confidence Intervals
          Linear Regression
          Multivariate Analysis
          Male
          Female
          Adult
          Middle Age
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: Background: Left ventricular global longitudinal strain (LVGLS) by speckle‐tracking transthoracic echocardiography (TTE) is an established measure of left ventricular systolic function with many clinical applications. Strain software has evolved to achieve vendor‐neutrality in recent developments, although there is a notable absence of external validation studies. We assessed the normal ranges and associated factors of two‐dimensional LVGLS quantification by TomTec, EchoPAC, VVI, and Epsilon contemporary strain software in a healthy cross‐sectional cohort. Methods: One hundred healthy subjects undergoing TTE during January–April 2023 at our institution were cross‐sectionally recruited, 20 per age‐group, 50% were female, and 50% had GE and 50% Philips scans. TomTec version 51.02 (Autostrain LV), EchoPAC version 206 (AFI‐LV), VVI version (V.2.00‐070730), and Epsilon (5.0.2.11295) were utilized to quantify two‐dimensional LVGLS in all patients for comparative and regression analyses. Results: Means and lower limits of normal (95% confidence intervals) of LVGLS were −17.1% (−17.5%, −16.7%) and −14.7% (−15.4%, −14.0%) for TomTec; −17.8% (−18.4%, −17.2%) and −14.4% (−15.3%, −13.5%) for EchoPAC; −16.3% (−16.9%, −15.7%) and −13.0% (−13.9%, −12.1%) for VVI; and −17.0% (−17.6%, −16.4%) and −12.8% (−13.8%, −11.8%) for Epsilon. Factors significantly associated with LVGLS measurements in multivariable regression analyses with their beta‐coefficients (95% CI) were female −1.36 (−2.12, −0.59), heart rate (per 10 bpm) with a coefficient of 0.38 (0.10–0.66), left ventricular ejection fraction (per 10%) −1.03 (−1.72, −0.34), and EchoPAC (vs. TomTec) −0.62 (−1.2, 0.0), VVI (vs. TomTec) 0.82 (0.23, 1.41) and Epsilon (vs. TomTec) 0.13 (−0.45, 0.72). Conclusion: LVGLS measurements were feasible across all four strain software on both GE and Philips scans in this study. Reference ranges to define normal, abnormal, and borderline LVGLS values along with associated factors in healthy patients are reported to enable clinical applications.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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