The Effect of Nurse-Led Intervention on the Healing of Diabetic Foot Ulcers with Ozonated Olive Oil: A Randomized Controlled Trial.

Background: Diabetic foot ulcers (DFUs) are a common and challenging complication of diabetes, often requiring prolonged and complex treatments. Innovative and effective therapies are crucial for improving wound healing. Ozonated olive oil, with its potential anti-inflammatory and antioxidant proper...

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Publicado en:Journal of Nursing & Midwifery Sciences Vol. 12; no. 1; pp. 1 - 14
Autores principales: Niasar, Alireza Abasi, Abdi, Fatemeh, Jandaghian-Bidgoli, Mohammadamin, Amirdehi, Mahdi Akbarzadeh, Bahrami, Tahereh, Khanchemehr, Yaser, Yaghobi, Mokhtar, Safa, Azade
Formato: research tables/charts randomized controlled trial Journal Article
Publicado: Brieflands Mar2025
Acceso en línea:Ver este registro en EBSCOhost
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        atl: The Effect of Nurse-Led Intervention on the Healing of Diabetic Foot Ulcers with Ozonated Olive Oil: A Randomized Controlled Trial.
      aug:
        au:
          Niasar, Alireza Abasi
          Abdi, Fatemeh
          Jandaghian-Bidgoli, Mohammadamin
          Amirdehi, Mahdi Akbarzadeh
          Bahrami, Tahereh
          Khanchemehr, Yaser
          Yaghobi, Mokhtar
          Safa, Azade
        affil: Baqiyatallah University of Medical Sciences, Tehran, Iran
      sug:
        subj:
          Diabetic Foot Nursing
          Diabetic Foot Drug Therapy
          Nursing Interventions
          Ozone Therapeutic Use
          Olive Oil Therapeutic Use
          Wound Healing Evaluation
          Human
          Iran
          Adolescence
          Adult
          Middle Age
          Aged
          Male
          Female
          Diabetic Patients
          Randomized Controlled Trials
          Random Assignment
          Wound Care
          Confidence Intervals
          Prospective Studies
          Caregivers
          Descriptive Statistics
          Scales
          T-Tests
          Comparative Studies
          Wound Measurement
          Ankle Brachial Index
          Nursing Outcomes
          Outpatients
          Clinical Assessment Tools
          Adolescent: 13-18 years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Male
          Female
      ab: Background: Diabetic foot ulcers (DFUs) are a common and challenging complication of diabetes, often requiring prolonged and complex treatments. Innovative and effective therapies are crucial for improving wound healing. Ozonated olive oil, with its potential anti-inflammatory and antioxidant properties, may offer a promising alternative for wound management. Objectives: The objective of this randomized controlled trial is to evaluate the effect of ozonated olive oil on the healing of DFUs. Methods: This study employed a prospective, randomized, controlled trial design with a parallel-group setup from July 20 to September 1, 2023, at a private outpatient clinic. Participants, aged 18 - 75 with type 1 or type 2 diabetes and DFUs, were randomly assigned to either a control or intervention group. The control group received standard wound care, while the intervention group had ozonated olive oil applied. The outcomes included wound healing, assessed using the Wagner wound classification and a checklist for evaluating the healing progress of DFUs. Statistical analysis was performed using SPSS version 22, with significance set at P ≤ 0.05. Results: The average age of participants in the intervention group was 58.33 years ± 6.13, while the control group had an average age of 63.80 ± 6.53. In this study, comparisons between the intervention and control groups revealed no significant differences in gender, marital status, employment status, or other similar demographic variables (P > 0.05). After a 4-week intervention, the wound degree (75.1389 ± 8.74121), color (46.714 ± 10.77), surrounding tissue condition (70.55 ± 7.346), and wound healing status (P < 0.001) were significantly improved after week 4 in the intervention group. The analysis showed that the intervention group consistently demonstrated higher effect sizes compared to the control group in terms of overall wound characteristics, with the intervention group's 95% confidence interval ranging from 180.649 at baseline to 311.912 at time point 4, while the control group's 95% confidence interval ranged from 179.856 to 214.469 (effect size of 0.878 for the intervention and 0.02 for the control group). Conclusions: Our study underscores the pivotal role of ozonated olive oil in the management of DFUs. Such nurse-led interventions can significantly accelerate wound healing. This highlights the potential of nursing-centered care models in optimizing outcomes for patients with chronic wounds. Future research should explore the long-term benefits of the intervention and its applicability to diverse populations.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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