"I'm tired of seeing my friends die": Barriers and facilitators to participating in clinical trials among rural people who use drugs in the United States.
Purpose: Participation in clinical trials among people who use drugs (PWUD) in rural areas remains disproportionately low compared to those in urban communities. Our objective was to describe the barriers and facilitators to clinical trial participation among this understudied and underserved popula...
| Published in: | Journal of Rural Health Vol. 41; no. 1; pp. 1 - 10 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Jan2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183950441&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183950441 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0890765X GUO jtl: Journal of Rural Health issn: 0890765X maglogo: Y pubinfo: dt: Jan2025 vid: 41 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 183950441 183950441 183950441 10.1111/jrh.70009 183950441 ppf: 1 ppct: 9 formats: tig: atl: "I'm tired of seeing my friends die": Barriers and facilitators to participating in clinical trials among rural people who use drugs in the United States. aug: au: Lancaster, Kathryn E. Estadt, Angela T. Enderle, Madison N. Korthuis, Todd P. Young, April M. affil: Department of Implementation Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston‐Salem North Carolina,, USA sug: subj: Health Services Accessibility United States Clinical Trials Rural Areas United States Persons with Substance Use Disorders United States Research Subjects Consumer Participation United States Special Populations Human Funding Source United States Semi-Structured Interview Kentucky Ohio Oregon Researcher-Subject Relations Qualitative Studies Adult Descriptive Statistics Male Female Interviews Motivation Communities Research Subject Retention Adult: 19-44 years Male Female ab: Purpose: Participation in clinical trials among people who use drugs (PWUD) in rural areas remains disproportionately low compared to those in urban communities. Our objective was to describe the barriers and facilitators to clinical trial participation among this understudied and underserved population. Methods: We conducted semi‐structured in‐depth interviews among rural PWUD in Kentucky, Ohio, and Oregon. Using the Ickovics and Meisler framework, we classified factors associated with participation in clinical trials among rural PWUD into five categories: the individual, trial and intervention characteristics, participant‐trial staff relationship, clinical trial setting, and features of the disease. We used inductive qualitative analysis methods to identify salient themes. Findings: Thirty‐five rural participants (median age: 39, 51% men) completed in‐depth interviews. Facilitators for rural clinical trial participation were mainly situated within the individual, trial and intervention characteristics, and clinical trial setting. Individual characteristics, such as altruistic motivations to help their communities and peers, as well as trial and intervention characteristics like visit reminders and resource assistance, were the most frequently noted facilitators of clinical trial participation. In contrast, participation barriers were mainly related to participant‐trial staff relationships and disease features. Judgmental and untrustworthy trial staff, along with involvement in the criminal legal system, were obstacles to clinical trial participation. Conclusions: Individual, intrapersonal, and logistical factors described by rural PWUD must be addressed to enhance the participation and retention of this population in clinical trials. Successful clinical trial participation may contribute to equitable access to essential health services by PWUD in rural communities. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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