A Direct Comparison of Three Screening Methods for Autism Spectrum Disorder in a High-Likelihood Sibling Population.
Targeted screening of children at increased likelihood of autism is recommended. However, autism screening tools are usually validated for use mainly in low-likelihood populations. This study compared the accuracy of the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F),...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 55; no. 4; pp. 1274 - 1286 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183973037&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183973037 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Apr2025 vid: 55 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 183973037 176263792 183973037 183973037 10.1007/s10803-024-06294-6 183973037 ppf: 1274 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A Direct Comparison of Three Screening Methods for Autism Spectrum Disorder in a High-Likelihood Sibling Population. aug: au: Wong, Chui Mae Mohd Zambri, Nurhafizah Fan, Hui Hua Lau, Lily H. S. Daniel, L. Mary Koh, Hwan Cui affil: https://ror.org/0228w5t68 Department of Child Development, KK Women's and Children's Hospital, 100 Bukit Timah Road, 229899, Singapore, Singapore sug: subj: Autism Spectrum Disorder Diagnosis Health Screening In Infancy and Childhood Siblings Checklists Instrument Validation Evaluation Human Funding Source Male Female Child Comparative Studies Sensitivity and Specificity Clinical Research Predictive Value of Tests Early Diagnosis International Relations Child: 6-12 years Male Female ab: Targeted screening of children at increased likelihood of autism is recommended. However, autism screening tools are usually validated for use mainly in low-likelihood populations. This study compared the accuracy of the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F), the ASDetect app, and the Social Attention and Communication Surveillance, Revised (SACS-R). Siblings of autistic children underwent autism screening at 12, 18 and 30 months old. At each visit, caregivers completed the M-CHAT-R/F and ASDetect while trained nurses tested the siblings using the SACS-R. At 36 to 48 months, the siblings underwent an Autism Diagnostic Observation Schedule—Second Edition (ADOS-2) assessment. 189 siblings were screened, 141 completed the study, and 32 were confirmed to have autism. Although not validated for use at 12 months, the M-CHAT-R/F had the best sensitivity among the three tools for this age group, suggesting that early signs are already apparent to caregivers. The M-CHAT-R/F had overall better sensitivity (0.72–0.83) across all age groups, but with overall lower specificity (0.55–0.77). The SACS-R and ASDetect had better positive predictive values at 18 and 30 months (0.60–0.68), while the M-CHAT-R/F was 0.43–0.48. Negative predictive values were generally high across all three tools across all age groups (0.78–0.93). Targeted screening of children at high likelihood of autism yielded a detection rate of 22.7% and should therefore be implemented routinely to facilitate early detection and intervention. The performance of autism screening tools should be examined in higher-likelihood populations for targeted screening of these children. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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