Family health beliefs and cascade genetic testing in Asian families with hereditary cancer risk: "Okay, now what?".
The limited literature on Asian family communication of hereditary cancer risk and cascade genetic testing for pathogenic variants (PVs) in BRCA1 and BRCA2 has reported that Asian patients have selective communication of test results and lower cascade testing rates. To better understand the factors...
| Publicado en: | Journal of Genetic Counseling Vol. 34; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=183983296&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 183983296 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10597700 41A jtl: Journal of Genetic Counseling issn: 10597700 maglogo: N pubinfo: dt: Feb2025 vid: 34 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 183983296 176107667 183983296 183983296 10.1002/jgc4.1891 183983296 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Family health beliefs and cascade genetic testing in Asian families with hereditary cancer risk: "Okay, now what?". aug: au: Tran, Leena Young, Jennifer L. Barton, Claire M. Hodan, Rachel Hanson‐Kahn, Andrea Chun, Nicolette affil: Stanford School of Medicine, Stanford University, Stanford California,, USA sug: subj: Asians Psychosocial Factors Genetic Screening Psychosocial Factors Communication Family Psychosocial Factors Health Beliefs Neoplastic Syndromes, Hereditary Risk Factors Genetic Screening Methods Human Qualitative Studies Health Belief Model Mutation Genes Evaluation Semi-Structured Interview Professional Role Disease Susceptibility Self-Efficacy Collaboration Decision Making, Family Family Support Health Information Anticipatory Guidance Genetic Screening Evaluation Funding Source ab: The limited literature on Asian family communication of hereditary cancer risk and cascade genetic testing for pathogenic variants (PVs) in BRCA1 and BRCA2 has reported that Asian patients have selective communication of test results and lower cascade testing rates. To better understand the factors that impact communication and cascade testing in Asian families, we conducted an in‐depth qualitative study guided by the Health Belief Model. Participants with heterozygous PVs in ATM, BRCA1, BRCA2, CHEK2, or PALB2, who identified their family's origins to an Asian country, were recruited from the Stanford Cancer Genetics Research Database in October–November 2021. Utilizing a constructivist approach, we conducted sixteen semi‐structured interviews around family communication and cascade genetic testing. The research team analyzed the transcript data using a reflexive thematic approach. Extensive discussions between the research team resulted in three primary themes presented in this paper: (1) the role of family health beliefs in cascade genetic testing, (2) changes in communication as a result of genetic testing, and (3) genetics providers' role in supporting family discussions on cascade genetic testing. Certain health beliefs, such as perceived susceptibility to cancer and self‐efficacy to take action, were co‐created by family members and these shared beliefs influenced decisions about genetic testing, family communication, and family support during the cascade genetic testing process. Participants shared strategies for how genetics providers can prepare Asian patients for more effective conversations with relatives and better address potential testing barriers by tailoring information and providing anticipatory guidance. This study represents an important contribution to the literature about cascade testing among an underrepresented group. Shared family health beliefs about genetic testing may be particularly relevant for this community and these findings can inform strategies to increase cascade genetic testing in Asian families. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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