Assessment of respiratory function in children after kidney transplantation.
Background: Severe respiratory complications following kidney transplantation have been reported, yet remain poorly understood in the pediatric population. This study aimed to document respiratory disease in this population. Methods: At annual follow-ups, patients completed a respiratory symptoms qu...
| Publicado en: | Pediatric Nephrology Vol. 40; no. 5; pp. 1771 - 1782 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184038182&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184038182 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: May2025 vid: 40 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 184038182 182090306 184038182 184038182 10.1007/s00467-024-06604-1 184038182 ppf: 1771 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Assessment of respiratory function in children after kidney transplantation. aug: au: Toubal, Marine Allain-Launay, Emma Bruel, Alexandra Sellier-Leclerc, Anne-Laure Dehoux, Laurène Novo, Robert Baudouin, Véronique Bihouee-Roussey, Tiphaine Roussey, Gwenaëlle Porcheret, Florence Bernard, Josselin affil: https://ror.org/00mthsf17 Childhood Chronic Diseases Department, University Hospital of Nantes, 7 Quai Moncousu, 44093, Nantes, France sug: subj: Kidney Transplantation Adverse Effects Postoperative Complications Respiratory Tract Diseases Symptoms Respiratory Tract Diseases Risk Factors Respiratory Tract Infections Risk Factors Risk Assessment Human Nonexperimental Studies Logistic Regression Odds Ratio Confidence Intervals Questionnaires Multivariate Analysis Respiratory Function Tests Lung Diseases, Obstructive Lung Volume Measurements Funding Source Sex Factors Polyomavirus Infections Bronchiectasis Tomography, X-Ray Computed Child Child: 6-12 years ab: Background: Severe respiratory complications following kidney transplantation have been reported, yet remain poorly understood in the pediatric population. This study aimed to document respiratory disease in this population. Methods: At annual follow-ups, patients completed a respiratory symptoms questionnaire and underwent pulmonary function tests (PFTs). We defined respiratory disease in children when they had clinical disorders and/or PFT abnormalities. Results: Among 236 children included, 110 (41%) exhibited respiratory involvement: 59 (53%) had only clinical disorders, 38 (35%) had only PFT abnormalities, and 13 (12%) had both. Of those with PFT abnormalities, 15 (7%) had obstructive impairment, 12 (6%) had restrictive impairment, and 30 (24%) showed decreased lung diffusion capacity for carbon monoxide (DLCO)/transfer coefficient for carbon monoxide (KCO). In the multivariate analysis, being over 3.5 years of age at the time of transplantation was associated with a reduced risk of respiratory involvement (OR 0.30, CI [0.14; 0.63], p = 0.002), such as induction with basiliximab (OR 0.39, CI [0.17; 0.90], p = 0.03). Conversely, history of immune deficiency, male gender, positive PCR for BK virus and diastolic hypertension were associated with an increased risk (OR 5.96, CI [2.15; 16.51], p = 0.0006, OR 1.97, CI [1.03; 3.77], p = 0.04, OR 3.77, CI [1.14; 12.52], p = 0.03 and OR 2.21, CI [1.13; 4.32], p = 0.02, respectively). Bronchial lesions, such as bronchiectasis, were predominantly observed on tomography. Conclusions: Given the risk of irreversible lung damage, we recommend systematic clinical and functional respiratory monitoring in case of respiratory symptoms, recurrent lower respiratory tract infections, and risk factors in their follow-up. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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