Automatic Diagnosis of Hepatocellular Carcinoma and Metastases Based on Computed Tomography Images.

Liver cancer, a leading cause of cancer mortality, is often diagnosed by analyzing the grayscale variations in liver tissue across different computed tomography (CT) images. However, the intensity similarity can be strong, making it difficult for radiologists to visually identify hepatocellular carc...

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Publicado en:Journal of Imaging Informatics in Medicine Vol. 38; no. 2; pp. 873 - 887
Autores principales: Zossou, Vincent-Béni Sèna, Rodrigue Gnangnon, Freddy Houéhanou, Biaou, Olivier, de Vathaire, Florent, Allodji, Rodrigue S., Ezin, Eugène C.
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Apr2025
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
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        10.1007/s10278-024-01192-w
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        atl: Automatic Diagnosis of Hepatocellular Carcinoma and Metastases Based on Computed Tomography Images.
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          Zossou, Vincent-Béni Sèna
          Rodrigue Gnangnon, Freddy Houéhanou
          Biaou, Olivier
          de Vathaire, Florent
          Allodji, Rodrigue S.
          Ezin, Eugène C.
        affil: https://ror.org/01ed4t417 Université Paris-Saclay, UVSQ, Univ. Paris-Sud, CESP, Équipe Radiation Epidemiology, 94805, Villejuif, France
      sug:
        subj:
          Carcinoma, Hepatocellular Diagnosis
          Neoplasm Metastasis Diagnosis
          Tomography, X-Ray Computed Methods
          Automation
          Human
          Funding Source
          Sensitivity and Specificity
          Neoplasm Invasiveness
          Convolutional Neural Networks Utilization
          Deep Learning
          Image Processing, Computer Assisted
          Descriptive Statistics
          McNemar's Test
          T-Tests
      ab: Liver cancer, a leading cause of cancer mortality, is often diagnosed by analyzing the grayscale variations in liver tissue across different computed tomography (CT) images. However, the intensity similarity can be strong, making it difficult for radiologists to visually identify hepatocellular carcinoma (HCC) and metastases. It is crucial for the management and prevention strategies to accurately differentiate between these two liver cancers. This study proposes an automated system using a convolutional neural network (CNN) to enhance diagnostic accuracy to detect HCC, metastasis, and healthy liver tissue. This system incorporates automatic segmentation and classification. The liver lesions segmentation model is implemented using residual attention U-Net. A 9-layer CNN classifier implements the lesions classification model. Its input is the combination of the results of the segmentation model with original images. The dataset included 300 patients, with 223 used to develop the segmentation model and 77 to test it. These 77 patients also served as inputs for the classification model, consisting of 20 HCC cases, 27 with metastasis, and 30 healthy. The system achieved a mean Dice score of 87.65 % in segmentation and a mean accuracy of 93.97 % in classification, both in the test phase. The proposed method is a preliminary study with great potential in helping radiologists diagnose liver cancers.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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