Downregulation of the Unfolded Protein Response Links Metformin Treatment to Good Clinical Outcomes in Colorectal Cancer Patients.

Type 2 diabetes is a risk factor for colorectal cancer (CRC) development and progression. However, metformin-treated diabetic CRC patients tend to have better clinical outcomes than those managed by other means. To better characterize the molecular underpinnings of metformin's protective effects, we...

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Bibliographic Details

Published in:	Current Oncology Vol. 32; no. 3; pp. 138 - 160
Main Authors:	Fay, Mary L., Nicol, Chris, Orr, Christine, Wilson, Brooke, Hurlbut, David, Feilotter, Harriet, Davey, Scott
Format:	Journal Article
Published:	MDPI Mar2025
Online Access:	View this record in EBSCOhost