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Pediatric CNS Radiation Oncology: Recent Developments and Novel Techniques.

Radiation therapy (RT) is a cornerstone in the management of pediatric central nervous system (CNS) tumors. Recent advancements in RT delivery and techniques aim to enhance therapeutic effectiveness while minimizing both acute and long-term complications associated with pediatric brain RT. This pape...

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Published in:Current Oncology Vol. 32; no. 3; pp. 180 - 208
Main Authors: Oh, Justin, Patel, Samir, Schlosser, Mary-Pat, Arifin, Andrew J., Oliveira, Carol, Charpentier, Anne-Marie, Tsang, Derek S.
Format: Journal Article
Published: MDPI Mar2025
Online Access:View this record in EBSCOhost
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      dt: Mar2025
      vid: 32
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      pub: MDPI
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        10.3390/curroncol32030180
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        atl: Pediatric CNS Radiation Oncology: Recent Developments and Novel Techniques.
      aug:
        au:
          Oh, Justin
          Patel, Samir
          Schlosser, Mary-Pat
          Arifin, Andrew J.
          Oliveira, Carol
          Charpentier, Anne-Marie
          Tsang, Derek S.
        affil: BC Cancer—Vancouver, Vancouver, BC V5Y 4E6, Canada
      sug:
      ab: Radiation therapy (RT) is a cornerstone in the management of pediatric central nervous system (CNS) tumors. Recent advancements in RT delivery and techniques aim to enhance therapeutic effectiveness while minimizing both acute and long-term complications associated with pediatric brain RT. This paper highlights innovative developments in the field, including the clinical indications, benefits, and challenges of proton therapy and stereotactic radiotherapy. The ongoing refinement of risk-adapted RT volumes is highlighted, with examples of newly proposed germinoma RT volumes and hippocampal-sparing RT. Additionally, emerging experimental approaches, including FLASH therapy and theranostics, are also discussed as promising future directions. Further prospective, multi-institutional collaborative studies are essential to validate and expand upon the benefits outlined in this review.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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