Exploring Stigma and Self-Image: Mixed-Methods Insights from HIV Cure-Related Research Participants Undergoing Analytical Treatment Interruptions.
This mixed-methods study explored self-image among people with HIV participating in an HIV cure-related study involving analytical treatment interruptions (ATIs). Using both quantitative and qualitative approaches, we described how self-image emerged across study participation, focusing on internali...
| Publicado en: | AIDS Patient Care & STDs Vol. 39; no. 4; pp. 151 - 160 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184127583&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184127583 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10872914 33C jtl: AIDS Patient Care & STDs issn: 10872914 maglogo: N pubinfo: dt: Apr2025 vid: 39 iid: 4 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 184127583 184127583 184127583 10.1089/apc.2024.0254 184127583 ppf: 151 ppct: 9 formats: tig: atl: Exploring Stigma and Self-Image: Mixed-Methods Insights from HIV Cure-Related Research Participants Undergoing Analytical Treatment Interruptions. aug: au: Meanley, Steven Rodriguez Garcia, Lidia Lisha, Nadra E. Ahmed, Ali Korolkova, Anastasia Figueroa, Tony Nguyen, Elizabeth J. Peluso, Michael Cohn, Lillian B. Deeks, Steven Dubé, Karine Sauceda, John affil: Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA. sug: subj: Stigma HIV Infections Drug Therapy Research Subjects Psychosocial Factors Structured Treatment Interruption HIV-Positive Persons Psychosocial Factors Self Concept Evaluation HIV Infections Psychosocial Factors Human Multimethod Studies Interviews Thematic Analysis Motivation Altruism Emotions Empowerment Funding Source Anti-Retroviral Agents Therapeutic Use Adult Middle Age Aged Male Female Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: This mixed-methods study explored self-image among people with HIV participating in an HIV cure-related study involving analytical treatment interruptions (ATIs). Using both quantitative and qualitative approaches, we described how self-image emerged across study participation, focusing on internalized stigma, emotional strengths, and the psychosocial dimensions of study participation. Data come from the SCOPE-ATI substudy (NCT00187512) of the University of California San Francisco SCOPE cohort (NCT04359186). Quantitative data were collected at three timepoints: pre-ATI (n = 15), post-ATI (n = 12), and end of the study (n = 14). We observed a general decline in self-image scores over time. However, participants maintained a moderately high agreement with statements about contributing to reducing HIV stigma through their involvement in the study. Qualitative interviews were collected pre-ATI (n = 11), during ATI (n = 8), and post-ATI (n = 6). Qualitative findings revealed two major themes shaping self-image: (1) experiencing and reconciling internalized HIV stigma and (2) self-evaluations in relation to life purpose. Many participants expressed disappointment at having to resume antiretroviral therapy, viewing it as a reminder of their HIV status and its associated stigma. Nevertheless, some found purpose and pride in their participation, motivated by altruistic contributions to improving future HIV control options. The findings highlight the emotional complexities of participating in HIV cure research and underscore the need for psychosocial support throughout ATI studies. While most participants experienced a decline in self-image, some derived meaning and empowerment from their involvement. This study suggests that addressing emotional well-being and reinforcing participants' contributions to science can enhance their experience in future research. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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