Allele ages provide limited information about the strength of negative selection.
For many problems in population genetics, it is useful to characterize the distribution of fitness effects (DFE) of de novo mutations among a certain class of sites. A DFE is typically estimated by fitting an observed site frequency spectrum (SFS) to an expected SFS given a hypothesized distribution...
| Published in: | Genetics Vol. 229; no. 3; pp. 1 - 15 |
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| Main Authors: | , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
Mar2025
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| Online Access: | View this record in EBSCOhost |