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The auxiliary effect of vitamin D in the treatment of chronic rhinosinusitis with nasal polyposis, a clinical trial.

Background: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) is a prevalent chronic inflammatory disorder of the nasal cavity and paranasal sinus with benign polypoid masses. Recent evidence highlights the immunomodulatory role of Vitamin D (Vit D) in mitigating inflammation associated with CRSw...

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Publicado en:Acta Oto-Laryngologica Vol. 145; no. 4; pp. 313 - 319
Autores principales: Bakhshaee, Mehdi, Hosseini, Seyed Saeed, Zanghaei, Abolfazl, Najaf Najafi, Mona, Bavi, Fatemeh, Roshanzamir, Imaneh
Formato: research tables/charts randomized controlled trial Journal Article
Publicado: Taylor & Francis Ltd Apr2025
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Background: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) is a prevalent chronic inflammatory disorder of the nasal cavity and paranasal sinus with benign polypoid masses. Recent evidence highlights the immunomodulatory role of Vitamin D (Vit D) in mitigating inflammation associated with CRSwNP. Aims: The aim of this study is to examine the effect of Vit D on the improvement of CRSwNP. Material and methods: This randomized, double-blind clinical trial was conducted on 59 patients with CRSwNP. All patients with Vit D deficiency (25OH Vit D level < 20 ng/mL) or insufficiency (<30 ng/mL) underwent endoscopic sinus surgery (ESS). The rate of changes in the patients' symptoms were recorded before and 8 weeks after the surgery. Result: All patients showed a better postsurgical improvement in terms of Visual Analogue Scale(VAS), Lund-Kennedy (LK), and Questionnaire (SNOT-22) scores. The Vit D supplement group showed better postsurgical improvement in comparison to placebo in terms of VAS and LK scores (p = 0.02, p = 0.03 respectively). Conclusions and significance: The administration of Vit D after ESS is relatively effective in the improvement of CRSwNP symptoms. This finding highlights the possibility of developing an efficient, safe, and cost-effective therapy for patients with CRSwNP.
伴有鼻息肉的慢性鼻窦炎 (CRSwNP) 是一种常见的带有良性息肉样肿块的鼻腔和鼻旁窦慢性炎症性疾病。最近的证据强调了维生素 D (Vit D) 在减轻与 CRSwNP 相关的炎症的免疫调节作用。 本研究旨在研究维生素 D 对 CRSwNP 改善的影响。 这项随机双盲临床试验针对 59 名 CRSwNP 患者进行。所有维生素 D 缺乏 (25OH 维生素 D 水平 < 20ng/mL) 或不足 (<30ng/mL) 的患者均接受了内镜鼻窦手术 (ESS)。记录了患者术前和术后 8 周症状的变化率。 所有患者在视觉模拟量表 (VAS)、Lund-Kennedy (LK) 和问卷 (SNOT-22) 评分方面均表现出术后改善。与安慰剂组相比, 维生素 D 补充剂组在 VAS 和 LK 评分方面表现出更好的术后改善(分别为 p = 0.02、p = 0.03)。 内镜鼻窦手术后服用维生素 D 对改善 CRSwNP 症状相对有效。这一发现突显了为 CRSwNP 患者开发一种有效、安全且经济实惠的治疗方法的可能性。