Angiotensin-converting gene and hypoxic exercise tolerance: a randomized crossover trial.
Hypoxic training enhances endurance sports tolerance. However, individual responses vary due to physiological differences. This study investigated the relationship between genetic factors and exercise tolerance in hypoxic conditions. This randomized crossover study included 22 male university studen...
| Publicado en: | International Journal of Sports Medicine Vol. 46; no. 4; pp. 246 - 255 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Georg Thieme Verlag Stuttgart
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184177737&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184177737 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01724622 NH4 jtl: International Journal of Sports Medicine issn: 01724622 maglogo: N pubinfo: dt: Apr2025 vid: 46 iid: 4 pid: 4536 pub: Georg Thieme Verlag Stuttgart artinfo: ui: 184177737 184177737 184177737 10.1055/a-2477-0512 184177737 ppf: 246 ppct: 9 formats: tig: atl: Angiotensin-converting gene and hypoxic exercise tolerance: a randomized crossover trial. aug: au: Muramoto, Yuki Momoi, Mizuki Nakashima, Daisuke Omae, Kakeru Sugai, Kazuhisa Daigo, Kyohei Iwasawa, Yuji Ichihara, Genki Okawara, Hiroki Sawada, Tomonori Kinoda, Akira Yamada, Yuichi Kimura, Takeshi Sato, Kazuki Katsumata, Yoshinori affil: RIN34787Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan sug: subj: Angiotensin-Converting Enzyme Polymorphism, Genetic Exercise Tolerance Evaluation Anoxia Human Male Adult Students, College Prospective Studies Randomized Controlled Trials Random Assignment Crossover Design Descriptive Statistics Oxygen Consumption Lactates Blood Genotype Oxygen Saturation Adult: 19-44 years Male ab: Hypoxic training enhances endurance sports tolerance. However, individual responses vary due to physiological differences. This study investigated the relationship between genetic factors and exercise tolerance in hypoxic conditions. This randomized crossover study included 22 male university students (age 20.8±1.3 years, peak oxygen uptake 54.5±6.5 mL/min/kg). Incremental load tests were conducted to assess the symptomatic limit on separate days under normoxic and hypoxic conditions (oxygen concentration 15.4±0.8%) using an ergometer. The initial test environment was randomized. The peak oxygen uptake and blood lactate were monitored every minute, and Δ peak oxygen uptake (peak oxygen uptake under hypoxia – peak oxygen uptake under normoxia) was calculated. Sixteen genotypes linked to exercise tolerance (such as angiotensin-converting enzyme [ACE]) were examined. Peak oxygen uptake significantly decreased under hypoxia (p<0.01). Δ peak oxygen uptake varied among individuals (minimum: 0.7 and maximum: − 18.9). Among analyzed genetic polymorphisms, ACE-II genotypes showed significantly greater Δ peak oxygen uptake than ACE-ID/ACE-DD genotypes (p=0.02). ACE-II genotypes exhibited lower blood lactate elevation at peak exercise in normoxic (p=0.01) and hypoxic (p=0.03) conditions. Participants with the ACE-II genotype had lower lactate concentrations and greater reductions in peak oxygen uptake under hypoxic conditions. Optimizing hypoxic training requires individualized programs incorporating genetic analysis. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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