Comparing the Effectiveness and Safety of Intravenous Levetiracetam and Phenobarbital as First-Line Therapies for Neonatal Seizures: A Randomized Clinical Trial.
Objectives This randomized clinical trial aims to evaluate and compare phenobarbital and levetiracetam effectiveness and safety in controlling neonatal seizures as first-line therapeutic options. Materials & Methods Neonates with seizure manifestations presenting to the Bahrami Hospital from March 2...
| Published in: | Iranian Journal of Child Neurology Vol. 19; no. 2; pp. 65 - 76 |
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| Main Authors: | , , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Iranian Journal of Child Neurology
Spring2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184199760&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184199760 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17354668 A91T jtl: Iranian Journal of Child Neurology issn: 17354668 maglogo: N pubinfo: dt: Spring2025 vid: 19 iid: 2 pid: 56766 pub: Iranian Journal of Child Neurology place: Tehran, <Blank> artinfo: ui: 184199760 184199760 184199760 10.22037/ijcn.v19i2.45234 184199760 ppf: 65 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Comparing the Effectiveness and Safety of Intravenous Levetiracetam and Phenobarbital as First-Line Therapies for Neonatal Seizures: A Randomized Clinical Trial. aug: au: Khosroshahi, Nahideh Kamrani, Kamyar Moradi, Muhammadhosein Sadeghirad, Parisa Oskouie, Ayda Khabazi affil: Deviation of Pediatric Neurology, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran sug: subj: Seizures Drug Therapy Anticonvulsants Therapeutic Use Phenobarbital Therapeutic Use Patient Safety Evaluation Drug Efficacy Evaluation Drug Therapy, Combination Iran Human Male Female Infant, Newborn Randomized Controlled Trials Random Assignment Descriptive Statistics Length of Stay Infant Feeding Confidence Intervals Data Analysis Software T-Tests Wilcoxon Rank Sum Test Pearson's Correlation Coefficient Chi Square Test Analysis of Covariance Infant, Newborn: birth-1 month Male Female ab: Objectives This randomized clinical trial aims to evaluate and compare phenobarbital and levetiracetam effectiveness and safety in controlling neonatal seizures as first-line therapeutic options. Materials & Methods Neonates with seizure manifestations presenting to the Bahrami Hospital from March 2020 to March 2022 were enrolled in this study. Patients' data were recorded, including demographic findings, anthropometric measurements, birth characteristics, and laboratory findings. Patients were randomly divided into the phenobarbital and levetiracetam treatment groups. Outcomes defined as adverse effects, response to medication, time to start enteral feeding, and length of hospital stay were compared between the two treatment groups. Results The current study comprises 44 neonates divided into phenobarbital and levetiracetam groups. Seizure control among the two groups was not significantly different, with levetiracetam and phenobarbital groups showing seizure control of 68.2% and 59.1%, respectively. Moreover, no significant difference was observed regarding the duration of hospitalization and time to initiate feeding. No adverse effect was reported in either group. Conclusion This study showed no significant difference between levetiracetam and phenobarbital for neonatal seizure control. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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