Eye Tracking as a Tool for Detecting Alzheimer's Disease in People With Down Syndrome.
Background: Adults with Down syndrome (DS) experience an increased risk of Alzheimer's disease (AD). Valid cognitive assessments for adults with DS with severe/profound intellectual disability (ID) are needed. It is unclear whether eye tracking is feasible for detecting AD in DS. Method: Fifty‐three...
| Publicado en: | Journal of Intellectual Disability Research Vol. 69; no. 5; pp. 370 - 383 |
|---|---|
| Autores principales: | , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184225850&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184225850 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09642633 EUL jtl: Journal of Intellectual Disability Research issn: 09642633 maglogo: Y pubinfo: dt: May2025 vid: 69 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 184225850 183801203 184225850 184225850 10.1111/jir.13214 184225850 ppf: 370 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Eye Tracking as a Tool for Detecting Alzheimer's Disease in People With Down Syndrome. aug: au: Piro‐Gambetti, Brianna Krinsky‐McHale, Sharon Kovacs, Cynthia Handen, Benjamin Christian, Bradley Laymon, Charles M. Minhas, Davneet Luo, Weiquan Yoon, Dasoo Milton Fleming, Victoria L. Schworer, Emily Kirkorian, Heather Hartley, Sigan L. affil: Waisman Center, University of Wisconsin‐Madison, Madison Wisconsin,, USA sug: subj: Alzheimer's Disease Risk Factors Alzheimer's Disease Diagnosis Eye Movements Equipment and Supplies Down Syndrome Complications Intellectual Disability Severity of Disability Risk Assessment Human Funding Source Male Female Adult Cognition Disorders Positron-Emission Tomography Dementia Bivariate Statistics Alzheimer's Disease Pathology Adult: 19-44 years Male Female ab: Background: Adults with Down syndrome (DS) experience an increased risk of Alzheimer's disease (AD). Valid cognitive assessments for adults with DS with severe/profound intellectual disability (ID) are needed. It is unclear whether eye tracking is feasible for detecting AD in DS. Method: Fifty‐three adults with DS completed a visual paired comparison (VPC) task, a battery of cognitive measures, and underwent PET scanning. Study partners reported on the participant's dementia symptoms. Bivariate correlations assessed associations between eye‐tracking metrics and AD‐related pathology and symptomatology. Analyses included the full sample (n = 53) and a subgroup with an IQ ≤ 45 (n = 33). Results: Greater fixation duration during the habituation phase was associated with better cognitive performance on the Modified Cued Recall Test (mCRT) (intrusions: r = −0.39, p = 0.011) and less PET tau (r = −0.47, p = 0.014). Larger saccadic amplitudes during the test phase were associated with younger age (r = −0.45, p < 0.001), better cognitive performance on the mCRT (total: r = 0.31, p = 0.041; intrusions: r = −0.33, p = 0.032) and less PET Aβ (r = −0.40, p = 0.025). Greater preference to fixate on the novel image was associated with fewer dementia symptoms (count: r = −0.44, p = 0.002; duration: r = −0.38, p = 0.009). This pattern of significance remained for the subgroup with lower IQ scores. Conclusion: The VPC task is a potentially useful method for assessing AD‐related cognitive impairments in adults with DS across varying ID levels. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|