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Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases.

Introduction: With global aging, dementia prevalence rises. While long-chain saturated fatty acids show anti-cognitive decline potential, serum tricosanoic acid (C23:0)'s role in brain regions and cognition remains unclear. Methods: To confirm the association between C23:0 and cognition in the popul...

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Published in:Frontiers in Aging Neuroscience pp. 1 - 12
Main Authors: Yang, Ti, Zhang, Yue, Cai, Zeen, Wang, Ying, Deng, Shengqiong
Format: pictorial research tables/charts Journal Article
Published: Frontiers Media S.A. 2025
Online Access:View this record in EBSCOhost
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        16634365
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      jtl: Frontiers in Aging Neuroscience
      issn: 16634365
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      dt: 2025
      pid: 40038
      pub: Frontiers Media S.A.
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        184227627
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        184227627
        10.3389/fnagi.2025.1534303
        184227627
      ppf: 1
      ppct: 11
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        atl: Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases.
      aug:
        au:
          Yang, Ti
          Zhang, Yue
          Cai, Zeen
          Wang, Ying
          Deng, Shengqiong
        affil: Department of Clinical Pharmacy, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China
      sug:
        subj:
          Cognition In Old Age
          Fatty Acids, Saturated Blood
          Human
          Male
          Female
          Middle Age
          Aged
          Aged, 80 and Over
          Data Analysis Software
          Descriptive Statistics
          Comparative Studies
          Wilcoxon Rank Sum Test
          Logistic Regression
          Odds Ratio
          Confidence Intervals
          Funding Source
          China
          Gene Expression
          Alzheimer's Disease
          Surveys
          Correlational Studies
          Nonexperimental Studies
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Introduction: With global aging, dementia prevalence rises. While long-chain saturated fatty acids show anti-cognitive decline potential, serum tricosanoic acid (C23:0)'s role in brain regions and cognition remains unclear. Methods: To confirm the association between C23:0 and cognition in the population, we analyzed gene expression data from the Alzheimer's disease (AD) brain gene chip data set (GSE118553) available in the Gene Expression Omnibus (GEO) database. Additionally, we examined data from 1,127 adults aged 60 years and older who participated in the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2014. To explore potential metabolic pathways and mechanisms linking C23:0 to cognitive aging, the computational platform METAFlux was employed. Results: Differential gene expression analysis identified 335 downregulated and 477 upregulated genes in AD frontal cortex. Metabolite analysis showed 20 upregulated and 37 downregulated nutrients (including C23:0) in AD vs. controls. Population-level analysis (NHANES, n = 1,127) confirmed higher serum C23:0 associated with better cognitive function. Discussion: This study provides strong evidence for frontal cortex-specific reduced C23:0 in AD and highlights its potential as a serum cognitive marker.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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