Association of low bone mineral density and dementia in older women: insights from the Longevity Improvement and Fair Evidence Study.
Background Both osteoporosis and dementia have emerged as important public health challenges in Japan's aging population. This study aimed to investigate the impact of low bone mineral density (BMD) on the subsequent risk of dementia in older Japanese women aged ≥65 years, given the overlapping demo...
| Published in: | Age & Ageing Vol. 54; no. 3; pp. 1 - 10 |
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| Main Authors: | , , , , |
| Format: | Article |
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Oxford University Press / USA
Mar2025
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=184349369&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 184349369 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Mar2025 vid: 54 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 184349369 10.1093/ageing/afaf058 ppf: 1 ppct: 9 formats: tig: atl: Association of low bone mineral density and dementia in older women: insights from the Longevity Improvement and Fair Evidence Study. aug: au: Kawaguchi, Kengo Maeda, Megumi Murata, Fumiko Nakashima, Yasuharu Fukuda, Haruhisa affil: Kyushu University, Department of Health Care Administration and Management, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Kyushu University, Department of Orthopaedic Surgery, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan su: Japan Women Medical screening Osteoporosis diagnosis Osteoporosis prevention Dementia risk factors Dementia prevention Risk assessment Bone density Research funding Alzheimer's disease Descriptive statistics Longitudinal method Log-rank test Dementia Confidence intervals Data analysis software Proportional hazards models sug: subj: Women Medical screening Japan All Other Miscellaneous Ambulatory Health Care Services Osteoporosis diagnosis Osteoporosis prevention Dementia risk factors Dementia prevention Risk assessment Bone density Research funding Alzheimer's disease Descriptive statistics Longitudinal method Log-rank test Dementia Confidence intervals Data analysis software Proportional hazards models keyword: bone mineral density dementia older adult older people osteoporosis osteoporosis screening bone mineral density dementia older adult older people osteoporosis osteoporosis screening ab: Background Both osteoporosis and dementia have emerged as important public health challenges in Japan's aging population. This study aimed to investigate the impact of low bone mineral density (BMD) on the subsequent risk of dementia in older Japanese women aged ≥65 years, given the overlapping demographics of individuals affected by these two conditions. Methods This cohort study was conducted using osteoporosis screening data and insurance claims data from a municipality. We identified 8618 women (median age: 73 years) who underwent osteoporosis screening between April 2019 and March 2021. Participants with a BMD <80% of the young adult mean were assigned to a low-BMD group (n = 2297), whereas those with a BMD ≥80% were assigned to a control group (n = 6321). The study outcomes were new-onset all-cause dementia and Alzheimer's disease (AD). To estimate the risk of low BMD on these outcomes, we constructed Cox proportional hazards models that adjusted for covariates (age, care needs, year of cohort entry, comorbidities and medications) using inverse probability of treatment weighting. Results The low-BMD group had a significantly higher risk of developing both all-cause dementia (adjusted hazard ratio: 1.58, 95% confidence interval: 1.20–2.08) and AD (1.61, 1.11–2.36) than the control group over approximately 30 months of follow-up. Conclusion These findings suggest that low BMD is associated with medium-term onset of dementia. Osteoporosis screenings could be useful not only for the secondary prevention of osteoporosis, but also for the primary prevention of dementia. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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