The association between long-term PM2.5 exposure and risk for pancreatic cancer: an application of social informatics.
There is a profound need to identify modifiable risk factors to screen and prevent pancreatic cancer. Air pollution, including fine particulate matter (PM2.5), is increasingly recognized as a risk factor for cancer. We conducted a case-control study using data from the electronic health record (EHR)...
| Publicado en: | American Journal of Epidemiology Vol. 194; no. 3; pp. 730 - 738 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Mar2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184351224&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184351224 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029262 1X1 jtl: American Journal of Epidemiology issn: 00029262 maglogo: N pubinfo: dt: Mar2025 vid: 194 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 184351224 184351224 184351224 10.1093/aje/kwae271 184351224 ppf: 730 ppct: 8 formats: tig: atl: The association between long-term PM2.5 exposure and risk for pancreatic cancer: an application of social informatics. aug: au: Bhavsar, Nrupen A Jowers, Kay Yang, Lexie Z Guha, Sharmistha Lin, Xuan Peskoe, Sarah McManus, Hannah McElroy, Lisa Bravo, Mercedes Reiter, Jerome P Whitsel, Eric Timmins, Christopher affil: Department of Surgery, School of Medicine, Duke University, Durham, NC, United States sug: subj: Particulate Matter Environmental Exposure Pancreatic Neoplasms Risk Factors Risk Assessment Pancreatic Neoplasms Prevention and Control Social Determinants of Health Human Medical Informatics Case Control Studies Air Pollution Electronic Health Records Socioeconomic Factors Algorithms Logistic Regression Male Female Odds Ratio Confidence Intervals Funding Source Male Female ab: There is a profound need to identify modifiable risk factors to screen and prevent pancreatic cancer. Air pollution, including fine particulate matter (PM2.5), is increasingly recognized as a risk factor for cancer. We conducted a case-control study using data from the electronic health record (EHR) of Duke University Health System, 15-year residential history, NASA satellite fine particulate matter (PM2.5), and neighborhood socioeconomic data. Using deterministic and probabilistic linkage algorithms, we linked residential history and EHR data to quantify long-term PM2.5 exposure. Logistic regression models quantified the association between a 1 interquartile range (IQR) increase in PM2.5 concentration and pancreatic cancer risk. The study included 203 cases and 5027 controls (median age of 59 years, 62% female, 26% Black). Individuals with pancreatic cancer had higher average annual exposure (9.4 μg/m3) as compared to an IQR increase in average annual PM2.5, which was associated with greater odds of pancreatic cancer (odds ratio = 1.20; 95% CI, 1.00-1.44). These findings highlight the link between elevated PM2.5 exposure and increased pancreatic cancer risk. They may inform screening strategies for high-risk populations and guide air pollution policies to mitigate exposure. This article is part of a Special Collection on Environmental Epidemiology. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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