Implementing nanopore sequencing in a clinical laboratory: a social systems case.
The Molecular Pathology Department at Awanui Labs Wellington have been trialling the implementation of nanopore long-read sequencing since 2020, initially to assist the Infection Prevention and Control team. This case study explored the social systems that enabled or constrained this implementation....
| Publicado en: | New Zealand Journal of Medical Laboratory Science Vol. 79; no. 1; pp. 25 - 31 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
New Zealand Institute of Medical Laboratory Science
Mar2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184380116&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184380116 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11710195 H2G jtl: New Zealand Journal of Medical Laboratory Science issn: 11710195 maglogo: N pubinfo: dt: Mar2025 vid: 79 iid: 1 pid: 12822 pub: New Zealand Institute of Medical Laboratory Science artinfo: ui: 184380116 184380116 184380116 184380116 ppf: 25 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Implementing nanopore sequencing in a clinical laboratory: a social systems case. aug: au: Manning, Suzanne Bloomfield, Max Hutton, Samantha Burton, Megan Velasco, Charles Tarring, Claire White, Rhys van der Werff, Koen affil: Social Systems Team, Institute of Environmental Science and Research (ESR), Wellington, New Zealand sug: subj: Sequence Analysis Methods Nanostructures Clinical Laboratories New Zealand Social Sciences Cross Infection Prevention and Control Infection Control Methods Program Implementation Human Sequence Analysis History New Zealand Action Research Genetics, Microbial Interviews Focus Groups Technology, Medical Laboratory Personnel Policy Making Quality Control (Technology) Autonomy Costs and Cost Analysis Qualitative Studies Financial Support Intelligence Laboratory Equipment and Supplies Economics Product Acquisition Economics Funding Source Clinical Laboratories, Hospital ab: The Molecular Pathology Department at Awanui Labs Wellington have been trialling the implementation of nanopore long-read sequencing since 2020, initially to assist the Infection Prevention and Control team. This case study explored the social systems that enabled or constrained this implementation. The study found that implementation was enabled by systems that were set up to balance the need for continued service improvement through research and innovation with the need to maintain the current level of service to clinicians and ultimately, the patients. The process also allowed oversight and coordination by management while providing a reasonable degree of autonomy for the laboratory staff to conduct the trial, including the time and flexibility required to investigate and develop the protocols. There were several implementation challenges. One challenge related to introducing a novel and unfamiliar technology while maintaining a busy routine workload, fitting in with the other work in the laboratory and securing funding. However, the main challenge specific to nanopore sequencing were the issues around accessing bioinformatics expertise, providing adequate computing power for data analysis, and the more systemic issue of data infrastructure in the health sector. The bioinformatics expertise and upgraded computer requirements have been addressed at a local level; however, the issue of national health data infrastructure and governance must be addressed if the potential of nanopore sequencing is to be realised. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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