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Association between erythritol and lung cancer: a two-sample Mendelian randomization study.

Background: Sweeteners have been widely added to food and beverages due to their low-calorie and sweetening properties. However, the role of sweeteners in cancer risk has been a subject of extensive debate over the past few decades. Objective: We aimed to elucidate the causation between the commonly...

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Published in:Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 12
Main Authors: Zhao, Yongsheng, Zheng, Renyan, Luo, Kexin, Zhao, Haiyang, Xiang, Wanping
Format: research tables/charts Journal Article
Published: BioMed Central 4/7/2025
Online Access:View this record in EBSCOhost
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      dt: 4/7/2025
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      pub: BioMed Central
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        10.1186/s12986-025-00916-1
        184383987
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        atl: Association between erythritol and lung cancer: a two-sample Mendelian randomization study.
      aug:
        au:
          Zhao, Yongsheng
          Zheng, Renyan
          Luo, Kexin
          Zhao, Haiyang
          Xiang, Wanping
        affil: https://ror.org/01673gn35 Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, No. 1, South Maoyuan Road, Shunqing District, 637000, Nanchong City, Sichuan Province, China
      sug:
        subj:
          Lung Neoplasms Risk Factors
          Vasodilator Agents Adverse Effects
          Sweetening Agents Adverse Effects
          Risk Assessment
          Human
          Mendelian Randomization
          Genome Wide Association Study
          Descriptive Statistics
          Comparative Studies
          Cancer Screening
      ab: Background: Sweeteners have been widely added to food and beverages due to their low-calorie and sweetening properties. However, the role of sweeteners in cancer risk has been a subject of extensive debate over the past few decades. Objective: We aimed to elucidate the causation between the commonly used natural sweetener erythritol and the risk of lung cancer (LC) using Mendelian randomization (MR). Methods: Data on erythritol and its metabolites were obtained from publicly available genome-wide association studies data. Summary data on LC and its subtypes were obtained from a large-scale genetic study conducted by the Transdisciplinary Research of Cancer in Lung of the International Lung Cancer Consortium and the Lung Cancer Cohort Consortium. We conducted independent two-sample MR analyses to assess the causation between erythritol and LC and its subtypes. Results: The inverse variance weighted method of MR analysis showed no evidence supporting causation between erythritol and LC or its histological subtypes. Sensitivity analysis further supported the results. Conclusion: Our study findings do not support genetic association between erythritol and LC or its subtypes.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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