Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study.
With the increase in average life expectancy, age-related male menopause has become a cause of decreased quality of life in men. The present study investigated the efficacy and safety of powdered enoki mushroom extract containing adenosine (test food) for menopausal symptoms in middle-aged and elder...
| Publicado en: | Nutrients Vol. 17; no. 7; pp. 1208 - 1219 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
MDPI
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184440190&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184440190 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Apr2025 vid: 17 iid: 7 pid: 97109 pub: MDPI artinfo: ui: 184440190 184440190 184440190 10.3390/nu17071208 184440190 ppf: 1208 ppct: 11 formats: tig: atl: Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study. aug: au: Yamada, Shizuo Shirai, Michiyo Nagashima, Koji Mochizuki, Jun Ono, Ken Kageyama, Shinji affil: Center for Pharma-Food Research, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan sug: subj: Plant Extracts Therapeutic Use Plant Extracts Pharmacodynamics Mushroom, Edible Japan Adenosine Therapeutic Use Adenosine Pharmacodynamics Andropause Drug Effects Drug Efficacy Evaluation Patient Safety Evaluation Andropause Drug Effects Human Male Middle Age Aged Randomized Controlled Trials Random Assignment Double-Blind Studies Testosterone Blood Japan Funding Source Life Expectancy Age Factors Quality of Life Adenosine Administration and Dosage Scales Sexual Health Chi Square Test Stratified Random Sample Descriptive Statistics Data Analysis Software Middle Aged: 45-64 years Aged: 65+ years Male ab: With the increase in average life expectancy, age-related male menopause has become a cause of decreased quality of life in men. The present study investigated the efficacy and safety of powdered enoki mushroom extract containing adenosine (test food) for menopausal symptoms in middle-aged and elderly men based on an evaluation of Heinemann's Aging Males' Symptoms (AMS) scores. The test food and placebo were administered to healthy men with AMS scores of 27–49 for 12 weeks. AMS score (primary endpoint) and testosterone level (secondary endpoint) were evaluated before and 12 weeks after the intake of the test food and placebo. The intake of the test food for 12 weeks significantly improved the sexual subscale of the AMS. In the cumulative χ2 test, the number of subjects showing high improvement was significantly higher in the test food group than in the placebo food group. In a stratified analysis of subjects divided into two groups based on a change in total testosterone levels of <0.5 ng/mL and ≥0.5 ng/mL after the intake of the test food, the number of subjects with increased total testosterone levels of ≥0.5 ng/mL was significantly higher in the test food group than in the placebo group. These results suggest the beneficial effects of enoki mushroom extract on symptoms of male menopause. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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