The Relationship Between Low-Grade Inflammation and Common Femoral Artery Intima-Media Thickness in Newly Diagnosed Type 2 Diabetes Mellitus.
Background: Besides the observed risks in type 2 diabetes mellitus (T2DM), intima-media thickness (IMT) is a surrogate marker for early diagnosing atherosclerosis and assessing the risk of subsequent developing cardiovascular disease. Low-grade inflammation (LGI) plays an important role in the devel...
| Publicado en: | Clinical Medicine Insights: Endocrinology & Diabetes pp. 1 - 9 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | algorithm research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
4/11/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184443056&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184443056 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795514 B3KQ jtl: Clinical Medicine Insights: Endocrinology & Diabetes issn: 11795514 maglogo: Y pubinfo: dt: 4/11/2025 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 184443056 184443056 184443056 10.1177/11795514251323837 184443056 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Relationship Between Low-Grade Inflammation and Common Femoral Artery Intima-Media Thickness in Newly Diagnosed Type 2 Diabetes Mellitus. aug: au: Tien Nguyen, Son Dinh Le, Tuan Dinh, Hoa Trung Ho Thi Nguyen, Lan Thi Nguyen, Giang Hien Vu, Trinh Huy Nguyen, Thong Luong Cong, Thuc Van Nguyen, Binh Duy Nguyen, Toan Quang Nguyen, Huy Van Nguyen, Ba Dinh Thi Thanh, Thuy Duong Huy, Hoang affil: Department of Rheumatology and Endocrinology, Vietnam Military Medical University, Hanoi, Vietnam sug: subj: Inflammation Femoral Artery Physiopathology Diabetes Mellitus, Type 2 Risk Assessment Human Male Female Middle Age Aged Adult Descriptive Research Cross Sectional Studies Vietnam Multiple Linear Regression C-Reactive Protein Blood Albumins Blood Waist-Hip Ratio Systolic Pressure Diastolic Pressure Lipoproteins, LDL Cholesterol Blood Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Male Female ab: Background: Besides the observed risks in type 2 diabetes mellitus (T2DM), intima-media thickness (IMT) is a surrogate marker for early diagnosing atherosclerosis and assessing the risk of subsequent developing cardiovascular disease. Low-grade inflammation (LGI) plays an important role in the development of intima-media damage of blood vessels in diabetes. Compared with IMT in the carotid artery, thickening IMT in the femoral artery occurs earlier and well reflects atherosclerosis process in diabetes mellitus. Objectives: To investigate the relationship between LGI and common femoral artery IMT in patients with newly diagnosed T2DM. Methods: A descriptive and cross-sectional study on 332 patients with T2DM diagnosed for the first time administered to Vietnam National Hospital of Endocrinology. LGI is defined as patients with high sensitive C-reactive protein (hs-CRP) from 3 to 10 mg/L. hs-CRP-to-albumin ratio (CAR) was used as a marker for LGI. The position for IMT assessment is 2 cm from the bifurcation of the common femoral artery toward the groin following Pignoli's method by B-mode ultrasound. Results: Patients with LGI showed higher IMT than those without LGI (P <.05). In multivariate linear regression, CAR positively correlated with IMT after adjusting with age, waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and LDL-C, with a standardized beta of 0.296 and P <.001. There were significant differences in CAR among groups stratified by IMT. In the logistic regression model, covariates for gender, BMI, HbA1c, LDL-C, insulin resistance (HOMA-IR), triglyceride, and triglyceride-to-HDL ratio were adjusted. It was determined that the likelihood of an increase in IMT was 3.68 times higher than the baseline (Q1) risk for Q4 and 2.27 times higher for Q2 of CAR. There was a positive correlation between elevated levels of CAR and an increased risk of IMT. Conclusion: In patients with newly diagnosed T2DM, there is a relationship between LGI and common femoral artery IMT. Particularly, IMT positively correlated with CAR. Plain Language Summary: The relationship between low-grade inflammation and common femoral artery innermost layers thickness in newly diagnosed type 2 diabetes mellitus The arterial wall is composed of three layers, namely the inner, the medial, and the outer ones. The thickness of the innermost layers (the inner and medial) of the thigh artery is a surrogate marker for early diagnosis of atherosclerosis and assessing the risk of subsequently developing heart disease in diabetes. Low-level inflammation is important in developing damage to the blood vessels' innermost layers in diabetes. In this study, we aimed to assess the relationship between low inflammation and common femoral artery inner-to-medial thickness in patients with newly diagnosed diabetes. Patients with low inflammation showed greater arterial thickness than the counter group. An increment of low inflammation increases the thickness of the femoral artery's innermost layers. Patients with thicker femoral arterial innermost layers exhibit nearly 2 to 4 times higher risk of developing low inflammation. Besides, multifactorial control, which increases low inflammation, including blood pressure, apart from glycemic control, could enhance the inflammation status and improve the thickness of femoral arteries, reducing heart disease risks in newly diagnosed diabetes. pubtype: Academic Journal doctype: algorithm research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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