| Sumario: | Simple Summary: Skin paraneoplastic syndromes (SPNSs) are skin conditions linked to cancer but not caused by the tumor itself. These syndromes, such as erythroderma, pyoderma gangrenosum or acanthosis nigricans, often appear before or alongside cancer, serving as early warning signs. Early detection is crucial for prompt cancer treatment. However, diagnosing SPNSs is challenging due to their rarity and diverse symptoms. This article stresses the importance of healthcare professionals, particularly dermatologists and oncologists, in recognizing these signs. This article also highlights diagnostic criteria like Curth's criteria to connect skin conditions with underlying malignancies and improve early cancer diagnosis and patient outcomes. Skin paraneoplastic syndromes (SPNSs) are a group of disorders that arise as a consequence of cancer but are not directly related to the tumor mass itself. This review aims to provide a comprehensive overview of these syndromes, encompassing their pathophysiology, clinical features, diagnostic approaches, differential diagnosis, and management strategies. These syndromes, which include conditions such as Bazex syndrome, acanthosis nigricans, dermatomyositis, and necrolytic migratory erythema often manifest prior to or concurrently with a cancer diagnosis, serving as potential early warning signs of underlying malignancies. This review delves into the spectrum of SPNSs and their associations with specific cancer types. Special emphasis is placed on the critical role of dermatologists and oncologists in identifying these skin manifestations as potential markers of malignancy. By raising awareness of SPNSs, this paper highlights the pivotal importance of prompt recognition and intervention in reducing cancer-related mortality.
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