Effect of dose administration aids on adherence of self‐administered medications: a systematic review.

Aim: Failure to self‐administer a medication is the most common reason for non‐adherence. Dose administration aids (DAAs) are a simple and common solution to improve unintentional non‐adherence for oral tablets. They range from compartmentalised pill boxes and automated medication dispensing devices...

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Publicado en:Journal of Pharmacy Practice & Research Vol. 55; no. 2; pp. 90 - 102
Autores principales: Chaudhri, Kanika, Gnanenthiran, Sonali R., Williams, Anastasia, Kearney, Madeleine, Day, Richard O., Rodgers, Anthony, Atkins, Emily R.
Formato: research systematic review tables/charts Journal Article
Publicado: Wiley-Blackwell Apr2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2025
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: Effect of dose administration aids on adherence of self‐administered medications: a systematic review.
      aug:
        au:
          Chaudhri, Kanika
          Gnanenthiran, Sonali R.
          Williams, Anastasia
          Kearney, Madeleine
          Day, Richard O.
          Rodgers, Anthony
          Atkins, Emily R.
        affil: The George Institute for Global Health, UNSW Sydney, Newtown, Australia
      sug:
        subj:
          Medication Compliance
          Administration, Oral
          Self Administration
          Tablets
          Human
          Systematic Review
          Medline
          Embase
          CINAHL Database
          Cochrane Library
          Australia
          Funding Source
          Descriptive Statistics
          Self Report
      ab: Aim: Failure to self‐administer a medication is the most common reason for non‐adherence. Dose administration aids (DAAs) are a simple and common solution to improve unintentional non‐adherence for oral tablets. They range from compartmentalised pill boxes and automated medication dispensing devices to blister packs. The aim of this systematic review was to summarise the current literature assessing the impact of DAAs on medication adherence. Data sources: A search of MEDLINE, Embase, CINAHL, and the Cochrane Library was conducted from the beginning of each database until April 2023. Study selection: A search strategy and keywords list were developed with a medical research librarian. Two reviewers independently screened studies and extracted data. The primary outcome was to assess the effects of DAAs on medication adherence. The secondary outcome was to evaluate the changes in any health outcomes documented. The study was reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta‐analyses (PRISMA) 2020 statement and registered with PROSPERO (Study registration: CRD42018096087). Results: Twenty‐two randomised controlled trials were included. Median adherence improved within the intervention groups for self‐reported (95.5%, range: 88%–100% vs 84.5%, range: 83%–98%) and non‐self‐reported (88%, range: 54%–100% vs 70%, range: 83%–98%) adherence compared to usual care. However, self‐reported adherence was higher in both intervention and control groups than non‐self‐reported adherence. Measured changes to health outcomes included cardiovascular outcomes, plasma levels, cure rates for malaria, hospital admissions, venous thromboembolism, and anaemia. Even though self‐reported adherence levels were high, included studies did not report many statistically significant improvements in health outcomes with DAAs. Conclusion: The use of DAAs can considerably improve medication adherence, with limited data suggesting positive effects on patient outcomes. Healthcare providers should consider the use of these aids as part of a comprehensive treatment plan for patients who struggle with medication adherence.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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