Machine learning and deep learning models for preoperative detection of lymph node metastasis in colorectal cancer: a systematic review and meta-analysis.
Objective: To evaluate the diagnostic performance of Machine Learning (ML) and Deep Learning (DL) models for predicting preoperative Lymph Node Metastasis (LNM) in Colorectal Cancer (CRC) patients. Methods: A systematic review and meta-analysis were conducted following PRISMA-DTA and AMSTAR-2 guidel...
| Publicado en: | Abdominal Radiology Vol. 50; no. 5; pp. 1927 - 1942 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184452412&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184452412 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: May2025 vid: 50 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 184452412 180761540 10.1007/s00261-024-04668-z 184452412 ppf: 1927 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Machine learning and deep learning models for preoperative detection of lymph node metastasis in colorectal cancer: a systematic review and meta-analysis. aug: au: Abbaspour, Elahe Mansoori, Bahar Karimzadhagh, Sahand Chalian, Majid Pouramini, Alireza Sheida, Fateme Daskareh, Mahyar Haseli, Sara affil: https://ror.org/00cvxb145 Division of Musculoskeletal Imaging and Intervention, Department of Radiology, University of Washington, Seattle, WA, USA sug: ab: Objective: To evaluate the diagnostic performance of Machine Learning (ML) and Deep Learning (DL) models for predicting preoperative Lymph Node Metastasis (LNM) in Colorectal Cancer (CRC) patients. Methods: A systematic review and meta-analysis were conducted following PRISMA-DTA and AMSTAR-2 guidelines. We searched PubMed, Web of Science, Embase, and Cochrane Library databases until February 16, 2024. Study quality and risk of bias were assessed using the QUADAS-2 tool. Data were analyzed using STATA v18, applying random-effects models to all analyses. Results: Twelve studies involving 8321 patients were included, with most published in 2021–2024 (9/12). The pooled AUC of ML models for predicting LNM in CRC patients was 0.87 (95% CI: 0.82–0.91, I2:86.17) with a sensitivity of 78% (95% CI: 69–87%) and a specificity of 77% (95% CI: 64%-90%). In addition, when assessing the AUC reported by radiologists, both junior and senior radiologists had similar performance, significantly lower than the ML models. (P < 0.001). Subgroup analysis revealed higher AUCs in prospective studies (0.95, 95% CI: 0.87–1) compared to retrospective studies (0.85, 95% CI: 0.81–0.89) (P = 0.03). Studies without external validation exhibited significantly higher AUCs than those with external validation (P < 0.01). While there was no significant difference in AUC and sensitivity between the T1-T2 and T2-T4 stages, specificity was significantly higher in the T2-T4 stages than the low stages of T1 and T2 (95%, 95% CI: 92–98% vs. 61%, 95% CI: 44–78%; P < 0.01). Conclusion: ML models demonstrate strong potential for preoperative LNM staging and treatment planning in CRC, potentially reducing the need for additional surgeries and related health and financial burdens. Further prospective multicenter studies, with standardized reporting of algorithms, modality parameters, and LNM staging, are needed to validate these findings. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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