Benchmarking PathCLIP for Pathology Image Analysis.

Accurate image classification and retrieval are of importance for clinical diagnosis and treatment decision-making. The recent contrastive language-image pre-training (CLIP) model has shown remarkable proficiency in understanding natural images. Drawing inspiration from CLIP, pathology-dedicated CLI...

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Publicado en:Journal of Imaging Informatics in Medicine Vol. 38; no. 1; pp. 422 - 439
Autores principales: Zheng, Sunyi, Cui, Xiaonan, Sun, Yuxuan, Li, Jingxiong, Li, Honglin, Zhang, Yunlong, Chen, Pingyi, Jing, Xueping, Ye, Zhaoxiang, Yang, Lin
Formato: equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature Feb2025
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-024-01128-4
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        atl: Benchmarking PathCLIP for Pathology Image Analysis.
      aug:
        au:
          Zheng, Sunyi
          Cui, Xiaonan
          Sun, Yuxuan
          Li, Jingxiong
          Li, Honglin
          Zhang, Yunlong
          Chen, Pingyi
          Jing, Xueping
          Ye, Zhaoxiang
          Yang, Lin
        affil: https://ror.org/0152hn881 Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China
      sug:
        subj:
          Osteosarcoma Diagnosis
          Lung Neoplasms Diagnosis
          Pathology, Clinical
          Image Processing, Computer Assisted Methods
          Benchmarking
          Predictive Value of Tests Evaluation
          Human
          Funding Source
          Databases
          Algorithms
          Decision Making
          Fraud Prevention and Control
          Data Quality
          Validation Studies
          Performance Measurement Systems
          Data Analysis, Statistical
          Models, Theoretical
          Image Retrieval
          Deep Learning Methods
          Instrument Construction
      ab: Accurate image classification and retrieval are of importance for clinical diagnosis and treatment decision-making. The recent contrastive language-image pre-training (CLIP) model has shown remarkable proficiency in understanding natural images. Drawing inspiration from CLIP, pathology-dedicated CLIP (PathCLIP) has been developed, utilizing over 200,000 image and text pairs in training. While the performance the PathCLIP is impressive, its robustness under a wide range of image corruptions remains unknown. Therefore, we conduct an extensive evaluation to analyze the performance of PathCLIP on various corrupted images from the datasets of osteosarcoma and WSSS4LUAD. In our experiments, we introduce eleven corruption types including brightness, contrast, defocus, resolution, saturation, hue, markup, deformation, incompleteness, rotation, and flipping at various settings. Through experiments, we find that PathCLIP surpasses OpenAI-CLIP and the pathology language-image pre-training (PLIP) model in zero-shot classification. It is relatively robust to image corruptions including contrast, saturation, incompleteness, and orientation factors. Among the eleven corruptions, hue, markup, deformation, defocus, and resolution can cause relatively severe performance fluctuation of the PathCLIP. This indicates that ensuring the quality of images is crucial before conducting a clinical test. Additionally, we assess the robustness of PathCLIP in the task of image-to-image retrieval, revealing that PathCLIP performs less effectively than PLIP on osteosarcoma but performs better on WSSS4LUAD under diverse corruptions. Overall, PathCLIP presents impressive zero-shot classification and retrieval performance for pathology images, but appropriate care needs to be taken when using it.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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