The Use of fMRI Regional Analysis to Automatically Detect ADHD Through a 3D CNN-Based Approach.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by a reduced attention span, hyperactivity, and impulsive behaviors, which typically manifest during childhood. This study employs functional magnetic resonance imaging (fMRI) to use spontaneous brain acti...

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Publicado en:Journal of Imaging Informatics in Medicine Vol. 38; no. 1; pp. 203 - 217
Autores principales: Gülhan, Perihan Gülşah, Özmen, Güzin
Formato: equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature Feb2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Feb2025
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      pub: Springer Nature
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        atl: The Use of fMRI Regional Analysis to Automatically Detect ADHD Through a 3D CNN-Based Approach.
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          Gülhan, Perihan Gülşah
          Özmen, Güzin
        affil: https://ror.org/045hgzm75 Department of Electrical and Electronics Engineering, Institute of Science, Selcuk University, Konya, Turkey
      sug:
        subj:
          Attention Deficit Hyperactivity Disorder Diagnosis
          Brain Radiography
          Magnetic Resonance Imaging
          Convolutional Neural Networks
          Automation
          Decision Support Systems, Clinical
          Human
          Male
          Female
          Child
          Adolescence
          Adult
          Comparative Studies
          Descriptive Statistics
          Deep Learning
          Imaging, Three-Dimensional
          Resource Databases
          Attention Deficit Hyperactivity Disorder Physiopathology
          Attention Deficit Hyperactivity Disorder Classification
          Funding Source
          Child: 6-12 years
          Adolescent: 13-18 years
          Adult: 19-44 years
          Male
          Female
      ab: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by a reduced attention span, hyperactivity, and impulsive behaviors, which typically manifest during childhood. This study employs functional magnetic resonance imaging (fMRI) to use spontaneous brain activity for classifying individuals with ADHD, focusing on a 3D convolutional neural network (CNN) architecture to facilitate the design of decision support systems. We developed a novel deep learning model based on 3D CNNs using the ADHD-200 database, which comprises datasets from NeuroImage (NI), New York University (NYU), and Peking University (PU). We used fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) data in three dimensions and performed a fivefold cross-validation to address the dataset imbalance. We aimed to verify the efficacy of our proposed 3D CNN by contrasting it with a fully connected neural network (FCNN) architecture. The 3D CNN achieved accuracy rates of 76.19% (NI), 69.92% (NYU), and 70.77% (PU) for fALFF data. The FCNN model yielded lower accuracy rates across all datasets. For generalizability, we trained on NI and NYU datasets and tested on PU. The 3D CNN achieved 69.48% accuracy on fALFF outperforming the FCNN. Our results demonstrate that using 3D CNNs for classifying fALFF data is an effective approach for diagnosing ADHD. Also, FCNN confirmed the efficiency of the designed model.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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