Intergenerational transmission of psychopathology across three generations: the role of social support.

Psychopathology runs in families and affects functioning of individuals and their family members. This study assessed the intergenerational transmission of psychopathology risk across three generations, and the extent to which social support factors may protect against this transmission from parents...

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Publicado en:European Child & Adolescent Psychiatry Vol. 34; no. 4; pp. 1329 - 1341
Autores principales: Xerxa, Yllza, Hillegers, Manon H. J., Mesman, Esther, Tiemeier, Henning, Jansen, Pauline W.
Formato: research tables/charts Journal Article
Publicado: Springer Nature Apr2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2025
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00787-024-02562-z
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        atl: Intergenerational transmission of psychopathology across three generations: the role of social support.
      aug:
        au:
          Xerxa, Yllza
          Hillegers, Manon H. J.
          Mesman, Esther
          Tiemeier, Henning
          Jansen, Pauline W.
        affil: https://ror.org/018906e22 Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands
      sug:
        subj:
          Psychopathology Evaluation
          Parents Psychosocial Factors
          Grandparents Psychosocial Factors
          Mental Disorders Familial and Genetic
          Children of Impaired Parents Psychosocial Factors
          Support, Psychosocial
          Mental Disorders Risk Factors
          Risk Assessment
          Human
          Male
          Female
          Child
          Adolescence
          Adult
          Prospective Studies
          Anxiety
          Depression
          Questionnaires
          Descriptive Statistics
          Confidence Intervals
          Mental Health
          Social Factors
          Brief Symptom Inventory
          Scales
          Child: 6-12 years
          Adolescent: 13-18 years
          Adult: 19-44 years
          Male
          Female
      ab: Psychopathology runs in families and affects functioning of individuals and their family members. This study assessed the intergenerational transmission of psychopathology risk across three generations, and the extent to which social support factors may protect against this transmission from parents to their offspring. This study was embedded in Generation R, a multi-ethnic population-based cohort from fetal life onwards. Lifetime psychiatric disorders of grandparents were assessed with the Family Informant Schedule Criteria- updated for DSM-IV. Parental psychopathology was repeatedly measured by the Brief Symptom Inventory. Offspring psychopathology (ages 10 and 14) was assessed with the Brief Problem Monitor. Maternal and child social factors were assessed using questionnaire measures and a computerized peer nomination assessment. Our results show that the estimated additive interaction effect for the risk transmission of grandparental and pre- and postnatal parental psychopathology to offspring psychopathology was 23% (95% CI 19; 27). The joint effect of grandparental and parental psychopathology combined with maternal and child social support factors was 13% (95% CI 08; 17)], suggesting that social support factors diminished the intergenerational transmission of psychopathology from (grand)parents (G1 and G2) to offspring (G3). Transmission of psychopathology risk may have long-lasting developmental effects across generations. Social support factors reduced the vulnerability to the effects of psychopathology risk, underscoring the importance of the identification of buffering factors associated with good mental health in adolescents who are at high familial risk.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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