White matter injuries mediate brain age effects on cognitive function in cerebral small vessel disease.
Purpose: This study aims to investigate the potential effect of compromised structural integrity on cerebral aging and cognitive function in cerebral small vessel disease (CSVD). Methods: Fifty-five CSVD patients and 42 controls underwent three-dimensional T1-weighted imaging and diffusion tensor im...
| Published in: | Neuroradiology Vol. 67; no. 3; pp. 613 - 623 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Springer Nature
Mar2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184520924&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184520924 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Mar2025 vid: 67 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 184520924 183070754 184520924 184520924 10.1007/s00234-025-03568-3 184520924 ppf: 613 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: White matter injuries mediate brain age effects on cognitive function in cerebral small vessel disease. aug: au: Li, Yuanhao Tian, Tian Qin, Yuanyuan Zhang, Shun Liu, Chengxia Zhu, Wenzhen affil: https://ror.org/04xy45965 Department of Radiology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Jiefang Road 1095, Wuhan, China sug: subj: Cerebral Small Vessel Diseases Complications White Matter Pathology Brain Pathology Cognition Disorders Risk Factors Risk Assessment Aging Human Funding Source Male Female Middle Age Aged Neuroradiography Cerebral Cortex Anatomy and Histology Executive Function Memory Mediation Analysis Linear Regression Cognition Neuropsychological Tests Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: This study aims to investigate the potential effect of compromised structural integrity on cerebral aging and cognitive function in cerebral small vessel disease (CSVD). Methods: Fifty-five CSVD patients and 42 controls underwent three-dimensional T1-weighted imaging and diffusion tensor imaging. Relative brain age (RBA) was computed to assess cerebral aging. Variables of structural integrity included cortical thickness, cortical volume, white matter hyperintensity (WMH) volume, peak width of skeletonized mean diffusivity (PSMD), ventricular volume, and choroid plexus volume. Mini-Mental State Examination (MMSE) was conducted to assess general cognition. Trail Making Test (TMT) and Auditory Verbal Learning Test were administered to evaluate executive function and episodic memory, respectively. Mediation analysis and multivariate linear regression with interaction terms were performed to explore the differential impacts of RBA on cognitive function and structural integrity between CSVD patients and controls. Results: RBA was significantly increased in CSVD patients compared to controls (p < 0.001). White matter injuries as assessed with PSMD (mediation magnitude: 41.1%) and WMH volume (mediation magnitude: 56.9%) significantly mediated the relationship between CSVD pathologies and RBA (p < 0.001). Higher RBA was significantly correlated with poorer scores of MMSE, TMT-A, and TMT-B in CSVD patients (p < 0.01). Additionally, PSMD (mediation magnitude: 57.8% in MMSE, 48.3% in TMT-A, and 28.8% in TMT-B) and WMH volume (mediation magnitude: 55.1% in MMSE) significantly mediated the relationship between RBA and cognitive function (p < 0.05). Conclusion: White matter injuries play a critical role in the cerebral aging and cognitive decline in CSVD patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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