Trends in nanobody radiotheranostics.
As the smallest antibody fragment with specific binding affinity, nanobody-based nuclear medicine has demonstrated significant potential to revolutionize the field of precision medicine, supported by burgeoning preclinical investigations and accumulating clinical evidence. However, the visualization...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 6; pp. 2225 - 2239 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184671084&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184671084 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: May2025 vid: 52 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 184671084 182175440 10.1007/s00259-025-07077-6 184671084 ppf: 2225 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Trends in nanobody radiotheranostics. aug: au: Long, Xingru Cheng, Sixuan Lan, Xiaoli Wei, Weijun Jiang, Dawei affil: https://ror.org/00p991c53 Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave., 430022, Wuhan, Hubei, China sug: ab: As the smallest antibody fragment with specific binding affinity, nanobody-based nuclear medicine has demonstrated significant potential to revolutionize the field of precision medicine, supported by burgeoning preclinical investigations and accumulating clinical evidence. However, the visualization of nanobodies has also exposed their suboptimal biodistribution patterns, which has spurred collaborative efforts to refine their pharmacokinetic and pharmacodynamic profiles for improved therapeutic efficacy. In this review, we present clinical results that exemplify the benefits of nanobody-based molecular imaging in cancer diagnosis. Moreover, we emphasize the indispensable role of molecular imaging as a tool for evaluating and optimizing nanobodies, thereby expanding their therapeutic potential in cancer treatment in the foreseeable future. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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