[68Ga]Ga‑FAPI PET/CT in the evaluation of Langerhans cell histiocytosis: comparison with [18F]FDG PET/CT.
Purpose: We aimed to explore the value of [68Ga]Ga‑FAPI PET/CT for the evaluation of Langerhans cell histiocytosis (LCH) in comparison with [18F]FDG PET/CT. Methods: Thirty-two patients pathologically diagnosed with LCH were enrolled in this study. [68Ga]Ga‑FAPI and [18F]FDG PET/CT were performed wi...
| Published in: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 6; pp. 2187 - 2198 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
May2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184671094&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184671094 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: May2025 vid: 52 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 184671094 182316875 10.1007/s00259-025-07097-2 184671094 ppf: 2187 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: [68Ga]Ga‑FAPI PET/CT in the evaluation of Langerhans cell histiocytosis: comparison with [18F]FDG PET/CT. aug: au: Zhang, Wenjie Wu, Yu Guo, Linlin Li, Xin Shen, Guohua affil: https://ror.org/007mrxy13 Department of Nuclear Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, 610041, Chengdu, Sichuan, People's Republic of China sug: ab: Purpose: We aimed to explore the value of [68Ga]Ga‑FAPI PET/CT for the evaluation of Langerhans cell histiocytosis (LCH) in comparison with [18F]FDG PET/CT. Methods: Thirty-two patients pathologically diagnosed with LCH were enrolled in this study. [68Ga]Ga‑FAPI and [18F]FDG PET/CT were performed within 1 week to identify disease extent and status. The detectability and intensity of the involved organs were compared between these two tracers. Results: Thirty patients had active disease while two had non-active disease. In patients with active disease, the most commonly involved organ was bone (27/30), and [68Ga]Ga-FAPI PET/CT detected more osseous lesions (106/106) than [18F]FDG PET/CT (52/106). [68Ga]Ga-FAPI also identified liver, skin, and salivary gland involvement, which were often missed by [18F]FDG. Although both tracers detected thymus and pituitary gland involvement, [68Ga]Ga-FAPI demonstrated higher image contrast and more diagnostic confidence. Lymph node involvement, however, was not visualized by [68Ga]Ga-FAPI. Due to the superior sensitivity of [68Ga]Ga-FAPI, approximately 30% (10/30) of patients experienced reclassification in disease status or subtype. Furthermore, [68Ga]Ga‑FAPI appeared to be advantageous in response assessment. Conclusion: [68Ga]Ga-FAPI PET/CT outperforms [18F]FDG PET/CT in detecting osseous and extra-nodal lesions in LCH, providing a valuable tool for precise disease evaluation and treatment planning. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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