Qualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury.
Background: Studies of moderate-to-severe traumatic brain injury (TBI) report persistent clinical impairment post-injury. In the CENTURY-S study of deep brain stimulation (DBS) in chronic TBI, Schiff et al.'s paper, "Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized fe...
| Publicado en: | NeuroRehabilitation Vol. 56; no. 2; pp. 143 - 152 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Mar2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184672319&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184672319 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: Mar2025 vid: 56 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 184672319 182337359 184672319 184672319 10.1177/10538135241296732 184672319 ppf: 143 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Qualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury. aug: au: Gerber, Linda M Shulman, Kaiulani S Wright, Megan S Schiff, Nicholas D Fins, Joseph J affil: Department of Population Health Sciences, Weill Cornell Medical College, NY, NY, USA sug: subj: Deep Brain Stimulation Methods Thalamus Physiology Brain Injuries Therapy Brain Injuries Symptoms Executive Function Evaluation Human Male Female Adult Middle Age Qualitative Studies Severity of Illness Functional Status Cognition Evaluation Behavioral Symptoms Emotional Regulation Narratives Pretest-Posttest Design Semi-Structured Interview Family Attitudes Self Regulation Frustration Memory Attention Fatigue Prevention and Control Secondary Analysis Transcutaneous Electric Nerve Stimulation Methods Descriptive Statistics Data Analysis Software Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Studies of moderate-to-severe traumatic brain injury (TBI) report persistent clinical impairment post-injury. In the CENTURY-S study of deep brain stimulation (DBS) in chronic TBI, Schiff et al.'s paper, "Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study" demonstrated improvements in executive control. A companion narrative analysis by Fins et al., "Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury" Parts I and II described improvements in cognitive, behavioral, and emotional capabilities. Objective: The present study provides an aggregate symptom assessment utilizing pre- and post-DBS narratives from subjects and their family members. Methods: Drawing upon participants from the CENTURY-S study, Fins et al. conducted semi-structured interviews with five subjects with moderate-to-severe TBI and their family members. Transcripts were subsequently coded deductively and inductively in Dedoose by two independent investigators. Results: Subjects and families frequently volunteered memory and cognitive symptoms as well as difficulties with self-regulation, frustration, and irritability pre-DBS. Following stimulation, four subjects and four families noted improvement in memory and attention and focus, while three subjects and five families volunteered improvements in self-regulation. Fatigue improved in three subjects who previously reported this symptom and in one who did not. Conclusions: Secondary qualitative analysis of narrative data of DBS trial participants supports the incorporation of qualitative data as additional outcome measures in studies of DBS in TBI. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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