Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study).
Introduction: Premature coronary artery disease (PCAD) has an ascending trend especially in developing countries. This study have investigated the risk factors and severity of developing CAD across various Iranian ethnicities. Methods: This case-control study was done on 3015 Iranian patients underg...
| Published in: | Journal of Cardiovascular & Thoracic Research Vol. 17; no. 1; pp. 49 - 58 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Tabriz University of Medical Sciences
Mar2025
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184694406&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184694406 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085117 BL7R jtl: Journal of Cardiovascular & Thoracic Research issn: 20085117 maglogo: N pubinfo: dt: Mar2025 vid: 17 iid: 1 pid: 69573 pub: Tabriz University of Medical Sciences artinfo: ui: 184694406 184694406 184694406 10.34172/jcvtr.025.33190 184694406 ppf: 49 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study). aug: au: Moezi Bady, Seyed Ali Salmani, Fatemeh Zarepur, Ehsan Kazemi, Toba Partovi, Neda Hanafi Bojd, Nazanin Khosravi Bizhaem, Saeede Khosravi Farsani, Alireza Mohammadifard, Noushin Nouhi, Fereidoon Alikhasi, Hassan Sadeghi, Masoumeh Roohafza, Hamidreza Hassannejad, Razieh Rabiei, Katayoun Salehi, Nahid Solati, Kamal Lotfizadeh, Masoud Ghaffari, Samad Javanmardi, Elmira affil: Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran sug: subj: Coronary Arteriosclerosis Risk Factors Coronary Arteriosclerosis Ethnology Risk Assessment Decision Trees Algorithms Severity of Illness Indices Human Funding Source Multicenter Studies Case Control Studies Iran Iranians Ethnic Groups Male Female Middle Age Aged Aged, 80 and Over Comorbidity Coronary Angiography Methods Percutaneous Coronary Intervention Coping Questionnaires Depression Anxiety Reliability and Validity Economic Status Logistic Regression Preprocedural Fasting Blood Glucose Analysis Descriptive Statistics Comparative Studies Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Introduction: Premature coronary artery disease (PCAD) has an ascending trend especially in developing countries. This study have investigated the risk factors and severity of developing CAD across various Iranian ethnicities. Methods: This case-control study was done on 3015 Iranian patients undergoing coronary artery angiography, across highly populated Iranian ethnicities including Bakhtiari, Azari, Qashqai, Arab, Fars, Kurd, Gilak, and Lur. This study was performed over three years in 14 capitals of provinces in Iran headed by Isfahan Cardiovascular Research Center, by including men < 60 years old and women ≤ 70 years undergoing coronary artery angiography. If they had coronary stenosis above 75% (more than 50% in the left main), they were categorized as Case group .The effects of conventional risk factors as well as psychosocial ones including age, gender, weight, Body mass index (BMI), economic status, cigarette smoking, drugs of abuse, stress, anxiety, diabetes, hypertension, etc. were determined in each ethnicity using decision tree statistical method. Also, via logistic regression method, the odds of incidence of CAD in each ethnicity were specified against the Fars ethnicity (the predominant ethnicity in Iran). Results: The most common risk factor among different ethnicities was age and male gender. Also, among the Iranian ethnicities, Kurd had the lowest chance while Gilak and Azari had the highest chance of developing PCAD as compared to the Fars ethnicity. Investigation of the behavioral and psychological dimensions indicated that stress was significantly higher among those without coronary artery involvement as compared to those with this involvement. The decision tree model could predict that among Gilakis, Fasting blood sugar (FBS) above 126 and in Lurs opium as well as diastolic blood pressure above 85, and in Kurds male gender would considerably increase the odds of developing CAD. Conclusion: The model obtained from the decision tree indicated that although variables of age, gender, cigarette, and opium are among the main risk factors for involvement of coronary arteries among young adult patients, in different ethnicities, the risk level of each of these risk factors in incidence of PCAD is different. This means among Kurds, age, among Gilakis diabetes, and among Lurs opium are more important. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|