Social Vulnerability and Biological Aging in New York City: An Electronic Health Records-Based Study.
Chronological age is not an accurate predictor of morbidity and mortality risk, as individuals' aging processes are diverse. Phenotypic age acceleration (PhenoAgeAccel) is a validated biological age measure incorporating chronological age and biomarkers from blood samples commonly used in clinical p...
| Publicado en: | Journal of Urban Health Vol. 102; no. 2; pp. 240 - 250 |
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| Autores principales: | , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Springer Nature
Apr2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=184745566&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 184745566 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10993460 GMF jtl: Journal of Urban Health issn: 10993460 maglogo: N pubinfo: dt: Apr2025 vid: 102 iid: 2 pid: 237 pub: Springer Nature artinfo: ui: 184745566 10.1007/s11524-024-00948-7 ppf: 240 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P size: 950KB tig: atl: Social Vulnerability and Biological Aging in New York City: An Electronic Health Records-Based Study. aug: au: Knobel, Pablo Colicino, Elena Kloog, Itai Litke, Rachel Lane, Kevin Federman, Alex Mobbs, Charles Yitshak Sade, Maayan affil: https://ror.org/04a9tmd77 Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, Box 1057, 1 Gustave L. Levy Place, 10029, New York, NY, USA https://ror.org/04a9tmd77 Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, Friedman Brain Institute, New York, NY, USA https://ror.org/05qwgg493 Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA https://ror.org/04a9tmd77 Division of General Internal Medicine, Icahn School of Medicine, New York, NY, USA su: Age Medical sciences Socioeconomic factors Health equity Electronic health records sug: subj: Age Medical sciences Socioeconomic factors Health equity Electronic health records keyword: Biological aging Disparities Medical and Health Sciences Public Health and Health Services New York City Social vulnerability Biological aging Disparities Medical and Health Sciences Public Health and Health Services New York City Social vulnerability ab: Chronological age is not an accurate predictor of morbidity and mortality risk, as individuals' aging processes are diverse. Phenotypic age acceleration (PhenoAgeAccel) is a validated biological age measure incorporating chronological age and biomarkers from blood samples commonly used in clinical practice that can better reflect aging-related morbidity and mortality risk. The heterogeneity of age-related decline is not random, as environmental exposures can promote or impede healthy aging. Social Vulnerability Index (SVI) is a composite index accounting for different facets of the social, economic, and demographic environment grouped into four themes: socioeconomic status, household composition and disability, minority status and language, and housing and transportation. We aim to assess the concurrent and combined associations of the four SVI themes on PhenoAgeAccel and the differential effects on disadvantaged groups. We use electronic health records data from 31,913 patients from the Mount Sinai Health System (116,952 person-years) and calculate PhenoAge for years with available laboratory results (2011–2022). PhenoAge is calculated as a weighted linear combination of lab results, and PhenoAgeAccel is the differential between PhenoAge and chronological age. A decile increase in the mixture of SVI dimensions was associated with an increase of 0.23 years (95% CI 0.21, 0.25) in PhenoAgeAccel. The socioeconomic status dimension was the main driver of the association, accounting for 61% of the weight. Interaction models revealed a more substantial detrimental association for women and racial and ethnic minorities with differences in leading SVI themes. These findings suggest that neighborhood-level social vulnerability increases the biological age of its residents, increasing morbidity and mortality risks. Socioeconomic status has the larger detrimental role among the different facets of social environment. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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