A Rare Malignant Case of a Primary Pseudomyogenic Haemangioendothelioma of the Bone.
Pseudomyogenic haemangioendotheliomas (PMH) are exceedingly rare, mostly occurring in soft tissue, with malignant cases even more uncommon. In this report, we present a case of a 28-year-old male initially suspected of having a fibroblastic osteosarcoma of the right femur, which was then correctly d...
| Publicado en: | Current Oncology Vol. 32; no. 4; pp. 219 - 227 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
MDPI
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184749610&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184749610 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Apr2025 vid: 32 iid: 4 pid: 97109 pub: MDPI artinfo: ui: 184749610 10.3390/curroncol32040219 184749610 ppf: 219 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A Rare Malignant Case of a Primary Pseudomyogenic Haemangioendothelioma of the Bone. aug: au: Di Mauro, Annabella Tafuto, Salvatore Cannella, Lucia Collina, Francesca Neri, Giovanni Clemente, Ottavia D'Arbitrio, Imma Ricci, Francesca Lastoria, Secondo Ferrara, Gerardo De Chiara, Annarosaria affil: Pathology Unit, Istituto Nazionale Tumori, IRCCS—Fondazione G. Pascale, 80131 Napoli, Italy sug: ab: Pseudomyogenic haemangioendotheliomas (PMH) are exceedingly rare, mostly occurring in soft tissue, with malignant cases even more uncommon. In this report, we present a case of a 28-year-old male initially suspected of having a fibroblastic osteosarcoma of the right femur, which was then correctly diagnosed as a primary pseudomyogenic hemangioendothelioma of the bone with synchronous metastases to other skeletal segments. Molecular analysis through targeted RNA sequencing confirmed the correct diagnosis, revealing a fusion transcript ACTB::FOSB. To our knowledge, this is one of the few reported cases of suffering from multiple pathological fractures. The rapid skeletal progression and the onset of distant metastases in this case is highly unusual considering the typically indolent clinical course commonly reported in the literature for this tumor. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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