Narrative review on ethical and psychological issues raised by genetic and genomic testing in pediatric oncology care.
In pediatric oncology, genetic and genomic tests are proposed throughout the care pathway for many reasons (e.g., cancer characterization, identification of the most appropriate treatment, patient selection for clinical trials, identification of tissue/organ donors, or risk of relapse prediction). D...
| Publicado en: | Journal of Genetic Counseling Vol. 34; no. 2; pp. 1 - 13 |
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| Autores principales: | , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184767444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184767444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10597700 41A jtl: Journal of Genetic Counseling issn: 10597700 maglogo: N pubinfo: dt: Apr2025 vid: 34 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 184767444 184767444 184767444 10.1002/jgc4.1955 184767444 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Narrative review on ethical and psychological issues raised by genetic and genomic testing in pediatric oncology care. aug: au: Droin‐Mollard, Marion Hervouet, Lucile Lahlou‐Laforêt, Khadija de Montgolfier, Sandrine affil: UF de Psychologie et Psychiatrie de Liaison et d'Urgences, DMU Psychiatrie et Addictologie, et Département de Génétique, APHP, Centre‐Universités de Paris, Paris, France sug: subj: Pediatric Care Ethical Issues Oncologic Care Ethical Issues Genomics Ethical Issues Cancer Patients Psychosocial Factors Parental Attitudes Attitude of Health Personnel Patient Attitudes Ethics Sequence Analysis Psychology Child Child: 6-12 years ab: In pediatric oncology, genetic and genomic tests are proposed throughout the care pathway for many reasons (e.g., cancer characterization, identification of the most appropriate treatment, patient selection for clinical trials, identification of tissue/organ donors, or risk of relapse prediction). Despite the many different approaches (somatic or germline testing, targeted gene or genome sequencing), the implicated individuals are confronted with situations that may intersect and that are interesting to compare. No study has identified and analyzed the available works on these new practices in pediatric oncology. The aim of this narrative literature review was to describe the ethical and psychological perspectives of children with cancer, parents, and healthcare professionals when genetic or genomic testing is proposed as part of the cancer management. Eighteen articles met the inclusion criteria and were comprehensively coded using MAXQDA. Their analysis showed that concerning the subjective implications of genetic and genomic testing, the areas of ambivalence (desire of treatment, desire for knowledge, uncertainty, and guilt) reported by patients and their parents seem to mirror the healthcare professionals' concerns. The ethical and psychological issues about predisposition testing, long discussed in the context of hereditary retinoblastoma and Li‐Fraumeni syndrome, represent a useful starting point for a wider discussion of a genetic and genomic testing pathway in pediatric oncology more broadly. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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