Early life social complexity shapes adult neural processing in the communal spiny mouse Acomys cahirinus.
Rationale: Early life social rearing has profound consequences on offspring behavior and resilience. Yet, most studies examining early life development in rodents use species whose young are born immobile and do not produce complex social behavior until later in development. Furthermore, models of r...
| Publicado en: | Psychopharmacology Vol. 242; no. 5; pp. 1025 - 1041 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184872858&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184872858 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: May2025 vid: 242 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 184872858 174039014 10.1007/s00213-023-06513-5 184872858 ppf: 1025 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Early life social complexity shapes adult neural processing in the communal spiny mouse Acomys cahirinus. aug: au: Wallace, Kelly J. Dupeyron, Solanch Li, Mutian Kelly, Aubrey M. affil: https://ror.org/03czfpz43 Department of Psychology, Emory University, Atlanta, USA sug: ab: Rationale: Early life social rearing has profound consequences on offspring behavior and resilience. Yet, most studies examining early life development in rodents use species whose young are born immobile and do not produce complex social behavior until later in development. Furthermore, models of rearing under increased social complexity, rather than deprivation, are needed to provide alternative insight into the development of social neural circuitry. Objectives: To understand precocial offspring social development, we manipulated early life social complexity in the communal spiny mouse Acomys cahirinus and assessed long-term consequences on offspring social behavior, exploration, and neural responses to novel social stimuli. Methods: Spiny mouse pups were raised in the presence or absence of a non-kin breeding group. Upon adulthood, subjects underwent social interaction tests, an open field test, and a novel object test. Subjects were then exposed to a novel conspecific and novel group and neural responses were quantified via immunohistochemical staining in brain regions associated with social behavior. Results: Early life social experience did not influence behavior in the test battery, but it did influence social processing. In animals exposed to non-kin during development, adult lateral septal neural responses toward a novel conspecific were weaker and hypothalamic neural responses toward a mixed-sex group were stronger. Conclusions: Communal species may exhibit robust behavioral resilience to the early life social environment. But the early life environment can affect how novel social information is processed in the brain during adulthood, with long-term consequences that are likely to shape their behavioral trajectory. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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