Managing Coagulation Using the Sonoclot Analyzer in Patients With Disseminated Intravascular Coagulation.
Background: Evidence for the effectiveness of the Sonoclot analyzer in improving clinical outcomes in disseminated intravascular coagulation (DIC) is lacking. Objective: To evaluate the effectiveness of an algorithm based on the Sonoclot analyzer in improving the short-term prognosis of patients wit...
| Publicado en: | American Journal of Critical Care Vol. 34; no. 3; pp. 194 - 208 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
American Association of Critical-Care Nurses
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184874059&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184874059 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10623264 44L jtl: American Journal of Critical Care issn: 10623264 maglogo: N pubinfo: dt: May2025 vid: 34 iid: 3 pid: 2559 pub: American Association of Critical-Care Nurses place: Alisa Veijo, California artinfo: ui: 184874059 184874059 184874059 10.4037/ajcc2025807 184874059 ppf: 194 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Managing Coagulation Using the Sonoclot Analyzer in Patients With Disseminated Intravascular Coagulation. aug: au: Wan, Peng Geng, Yan Su, Lei Liu, Jinghua Tong, Huasheng Liu, Zhifeng Chen, Wenda Yu, Baojun Peng, Na affil: chief physician, Department of Critical Care Unit, First Clinical Medical College of Three Gorges University, Yichang, Hubei, China sug: subj: Disseminated Intravascular Coagulation Therapy Blood Coagulation Tests Equipment and Supplies Algorithms Disseminated Intravascular Coagulation Prognosis Human Prospective Studies Descriptive Statistics Heparin Therapeutic Use Comparative Studies Plasma Platelet Count Severity of Illness Data Analysis Software Analysis of Variance Post Hoc Analysis Wilcoxon Rank Sum Test Two-Way Analysis of Variance Kaplan-Meier Estimator Funding Source ab: Background: Evidence for the effectiveness of the Sonoclot analyzer in improving clinical outcomes in disseminated intravascular coagulation (DIC) is lacking. Objective: To evaluate the effectiveness of an algorithm based on the Sonoclot analyzer in improving the short-term prognosis of patients with DIC. Methods: A total of 279 patients with overt DIC who were admitted to the hospital within 18 months before and after implementation of the new Sonoclot-based algorithm were enrolled in the study. They were assigned to either a conventional coagulation assay (CCA) group (n = 148) or a Sonoclot group (n = 131). Data associated with anti-coagulation and transfusion were collected and analyzed. The 30-day survival rate after hospital admission was compared between groups. Results: The Sonoclot group had a higher 30-day survival rate than the CCA group (78.45% vs 63.64%; P =.02). The heparin dose, anticoagulation course, and major bleeding rate were significantly reduced in the Sonoclot group compared with the CCA group for all patients and for patients undergoing continuous renal replacement therapy (all P <.001). Fresh frozen plasma, platelet, and cryoprecipitate requirements were substantially lower in the Sonoclot group than in the CCA group (P =.007,.03, and.02, respectively). In a stratified analysis, improved survival rate was seen mainly in patients with moderately severe sepsis and heatstroke, with an Acute Physiology and Chronic Health Evaluation II score of 20 to 29. Conclusion: The Sonoclot analyzer may be useful to guide coagulation management in patients with DIC. Use of the Sonoclot-based algorithm may improve outcomes for DIC patients with moderately severe sepsis or heatstroke. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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