A spiral channel with integrated microelectrodes for label-free particle lateral position and size characterization.
Modified-trident shaped microelectrodes were incorporated into a spiral-shaped microfluidic focusing channel, utilizing impedance flow cytometry to analyze and quantify inertial microfluidic-based separation of homogeneous particles differing in size. Double peak voltage pulses were generated as par...
| Publicado en: | Biomedical Microdevices Vol. 27; no. 2; pp. 1 - 11 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184915789&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184915789 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872176 ODN jtl: Biomedical Microdevices issn: 13872176 maglogo: N pubinfo: dt: Jun2025 vid: 27 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 184915789 10.1007/s10544-025-00742-5 184915789 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A spiral channel with integrated microelectrodes for label-free particle lateral position and size characterization. aug: au: Peng, Yunhao Gale, Bruce K. Sant, Himanshu J. affil: https://ror.org/03r0ha626 Department of Chemical Engineering, Price College of Engineering, University of Utah, 50 S. Central Campus Dr. Room 3290 MEB, 84112-9203, Salt Lake City, UT, USA sug: ab: Modified-trident shaped microelectrodes were incorporated into a spiral-shaped microfluidic focusing channel, utilizing impedance flow cytometry to analyze and quantify inertial microfluidic-based separation of homogeneous particles differing in size. Double peak voltage pulses were generated as particles moved across the electrodes, where the ratio of the peak amplitudes indicated the lateral particle positions inside the channel at various flow rates, while the peak amplitude indicated particle size and vertical position. The root mean square error between the optical and electrical position measurements was 11.44 µm reflecting the lateral position measurement resolution. The peak amplitudes were used to estimate particle size after being adjusted to account for particle vertical position using a shape parameter, which effectively reduced errors in particle size calculations. The particle size estimate sensitivity was measured to be 2.15 μm/mV from the peak amplitudes. The electrodes with the appropriate signal processing were able to detect both the size and location of particles after separation with a spiral channel, showing their utility in potentially controlling the separation conditions for these devices. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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