Sex-specific differences in NAFLD development: effect of a high-sucrose diet on biochemical, histological, and genetic markers in C57bl/6N mice.
Sucrose intake is a potential risk factor for non-alcoholic fatty liver disease (NAFLD). Individual characteristics such as sex, play arole in the biological variation of the disease, potentially related to genetic regulation. This research evaluated sex differences in biochemical, histopathological...
| Publicado en: | International Journal of Environmental Health Research Vol. 35; no. 5; pp. 1237 - 1251 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184921630&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184921630 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: May2025 vid: 35 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 184921630 178873812 184921630 184921630 10.1080/09603123.2024.2386113 184921630 ppf: 1237 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Sex-specific differences in NAFLD development: effect of a high-sucrose diet on biochemical, histological, and genetic markers in C57bl/6N mice. aug: au: MJ, Vega Burgueño EH, Torres Montoya JM, Zazueta-Moreno EM, Barron-Cabrera U, Osuna-Martínez EJ, Urías-García TD, Salinas-Garza DA, Ochoa-Acosta MJ, Vergara-Jiménez affil: Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán de Rosales, México sug: subj: Sex Factors Nonalcoholic Fatty Liver Disease Risk Factors Dietary Sucrose Adverse Effects Biochemical Phenomena Gene Expression Biological Markers Histocytochemistry Risk Assessment Animal Studies Mice Tissue Analysis Liver Analysis Blood Analysis Descriptive Statistics Funding Source ab: Sucrose intake is a potential risk factor for non-alcoholic fatty liver disease (NAFLD). Individual characteristics such as sex, play arole in the biological variation of the disease, potentially related to genetic regulation. This research evaluated sex differences in biochemical, histopathological, and gene expression responses associated with NAFLD in C57bl/6N mice on a high sucrose diet. Female and male mice were assigned to control or high sucrose diets (50% sucrose solution) for 20 weeks. After sacrifice, blood and hepatic tissue were collected for analysis. Female mice revealed moderate-to-high NAFLD, whereas male mice showed mild-to-moderate NAFLD. Sex-specific variations were observed in Cd36 gene expression, an upregulation in females compared with the male group, and Adipor1 gene expression showed significant downregulation in the female group in response to high sucrose diet compared with the control group. These findings highlight the importance of considering gender disparities in the treatment and management of NAFLD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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