Association of multimorbidity patterns and order of physical frailty and cognitive impairment occurrence: a prospective cohort study.
Background Chronic conditions often co-occur in specific disease patterns. Certain chronic diseases contribute to incident frailty or cognitive impairment (CI), but the associations of multimorbidity patterns and the order of frailty and CI occurrence remain unclear. Objectives To determine multimor...
| Publicado en: | Age & Ageing Vol. 54; no. 4; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Apr2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=184925766&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 184925766 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Apr2025 vid: 54 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 184925766 10.1093/ageing/afaf101 ppf: 1 ppct: 10 formats: tig: atl: Association of multimorbidity patterns and order of physical frailty and cognitive impairment occurrence: a prospective cohort study. aug: au: Wang, Shuomin Li, Qianyuan Hu, Jianzhong Chen, Qirong Wang, Shanshan Xue, Qian-Li Huang, Chongmei Sun, Hongyu Liu, Minhui affil: Xiangya School of Nursing, Central South University, Changsha, China National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University, Changsha, China School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China School of Medicine, Johns Hopkins University, Baltimore, United States School of Nursing, Ningxia Medical University, Yinchuan, China School of Nursing, Peking University, Beijing, China su: Disease risk factors Old age Cognition disorder risk factors Risk assessment Research funding Independent living Frail elderly Structural equation modeling Cardiovascular diseases risk factors Descriptive statistics Longitudinal method Comorbidity Physical activity sug: subj: Disease risk factors Old age Cognition disorder risk factors Risk assessment Research funding Independent living Frail elderly Structural equation modeling Cardiovascular diseases risk factors Descriptive statistics Longitudinal method Comorbidity Physical activity keyword: cognitive impairment frailty latent class analysis multimorbidity multimorbidity pattern older adult older people physical frailty prospective studies cognitive impairment frailty latent class analysis multimorbidity multimorbidity pattern older adult older people physical frailty prospective studies ab: Background Chronic conditions often co-occur in specific disease patterns. Certain chronic diseases contribute to incident frailty or cognitive impairment (CI), but the associations of multimorbidity patterns and the order of frailty and CI occurrence remain unclear. Objectives To determine multimorbidity patterns amongst older adults and their associations with the order of frailty and CI occurrence. Design Prospective cohort study. Methods Using data from National Health and Aging Trends Study, 7522 community-dwelling participants were included and followed up for four years. Latent class analysis was conducted to identify multimorbidity patterns with clinical meaningfulness. Fine and Grey competing risks models were used to examine the associations between multimorbidity patterns and different orders of frailty and CI occurrence (frailty-first, CI-first, frailty-CI co-occurrence). Results Four multimorbidity patterns were identified: cardiometabolic, osteoarticular, cancer-dominated and psychiatric/multisystem pattern. Compared to non-multimorbidity, all four multimorbidity patterns were associated with a higher risk of developing frailty-first, but not developing CI-first. Specifically, the psychiatric/multisystem pattern had the highest risk of developing frailty-first ( Sub-distribution hazard ratios [SHR] = 3.74, 95% confidence intervals = 2.96, 4.71), followed by osteoarticular pattern (SHR = 2.53, 95% CI = 1.98, 3.22) and cardiometabolic pattern (SHR =2.41, 95% confidence intervals = 1.96, 2.98). In addition, only participants from psychiatric/multisystem and cardiometabolic pattern showed a higher risk of frailty-CI co-occurrence. Conclusions Our findings highlight the etiological heterogeneity between physical frailty and CI. Clinician should be aware of multimorbidity clusters and thus provide more effective strategies for comorbid older adults to prevent the onset of these two geriatric syndromes. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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